Evidence map›Paper›PMID 41465419›Full record

ArticleInternational journal of molecular sciences2025

Cysteine Attenuates Intestinal Inflammation by Regulating the Gut Microbiota and TLR4-JNK/MAPK-NF-κB Pathway in Piglets.

Rui Liu, Pengxiang Qin, Zihao Liu, Wenjing Liu, Shuzhen Jiang, Xuejun Yuan, Weiren Yang, Caiyun Huang, Ning Jiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rui LiuKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.
Pengxiang QinKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.
Zihao LiuKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.
Wenjing LiuKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.
Shuzhen JiangKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.ORCID 0000-0002-4943-0322
Xuejun YuanCollege of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.ORCID 0000-0002-7028-6732
Weiren YangKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.
Caiyun HuangCollege of Animal Science and Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Ning JiaoKey Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), College of Animal Science and Technology, Ministry of Agriculture and Rural Affairs, Shandong Agricultural University, Tai'an 271017, China.ORCID 0000-0002-5055-2159

Funding

National Natural Science Foundation of China 32402800
6 · The paper itself

Abstract

As a nutritionally important amino acid, cysteine (Cys) could attenuate oxidative damage on growth performance and intestinal barrier function in piglets. However, the mechanism of Cys in attenuating intestinal injury remains unclear. The aim of this study was to investigate the mechanism of Cys in defending against intestinal inflammation in piglets. A total of twenty-four piglets were divided into four groups and fed a diet with or without 0.1% BPA or Cys for a 28 d feeding trial. The results showed that Cys supplementation reinstated the jejunal barrier by increasing cell proliferation and the goblet cell number, and decreased cell apoptosis upon BPA exposure. Cys supplementation also decreased serum and jejunal pro-inflammatory cytokine and immunoglobulin levels in BPA-challenged piglets. Furthermore, Cys mitigated inflammation by normalizing the activation of the toll-like receptor 4 (TLR4)-JNK/MAPK-nuclear factor-kappa B (NF-κB) pathway caused by BPA. Additionally, dietary Cys supplementation restored the levels of butyrate, valerate and isovalerate in cecum contents that were decreased by BPA exposure. Meanwhile, Cys supplementation normalized the abundances of

Indexed as

CysteineGastrointestinal MicrobiomeInflammationMAP Kinase Signaling SystemToll-Like Receptor 4AnimalsDietary SupplementsIntestinal MucosaIntestinesNF-kappa BSignal TransductionSwineCysteineNF-kappa BToll-Like Receptor 4cysteinegut microbiotainflammationintestine

Identifiers

PMID41465419
PMCPMC12732415

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.