Evidence map›Paper›PMID 41465411›Full record

ArticleInternational journal of molecular sciences2025

LPS-Induced Neuroinflammation Increases Serotonin-Evoked Activity of Trigeminal Afferents and Aggravates Mechanical Allodynia and Photophobic Behavior in Rat Migraine Model.

Svetlana Svitko, Elisaveta Ermakova, Karina Gilizhdinova, Ksenia Bogatova, Nazgul Gaifutdinova, Dinara Nurmieva, Egor Nevsky, Anton Ananev, Olga Yakovleva, Albert Sufianov and 6 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Svetlana SvitkoDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0009-0003-1507-6120
Elisaveta ErmakovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-2045-5294
Karina GilizhdinovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0009-0005-9924-8907
Ksenia BogatovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-5711-2439
Nazgul GaifutdinovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0009-0005-8853-0659
Dinara NurmievaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Egor NevskyDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0009-0006-1358-5062
Anton AnanevDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0009-0006-4262-3865
Olga YakovlevaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-7002-7765
Albert SufianovPetrovsky National Research Center of Surgery, 119435 Moscow, Russia.ORCID 0000-0001-7580-0385
Galina Z SufianovaDepartment of Pharmacology, Tyumen State Medical University, 625023 Tyumen, Russia.
Artyom BaevLaboratory of Experimental Biophysics, Centre for Advanced Technologies, Tashkent 100174, Uzbekistan.ORCID 0000-0003-1582-5059
Kseniia ShaidullovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-3359-6918
Albert RizvanovDivision of Medical and Biological Sciences, Tatarstan Academy of Sciences, 420111 Kazan, Russia.ORCID 0000-0002-9427-5739
Aliya YakubovaDepartment of Gene and Cell Technology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420021 Kazan, Russia.ORCID 0000-0003-1118-8929
Guzel SitdikovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0001-5412-2204

Funding

The Ministry of Science and Higher Education of Russian Federation 075-15-2025-679
6 · The paper itself

Abstract

Migraine is characterized by severe pain and somatic symptoms like allodynia and photophobia, driven by neuroinflammation that sensitizes the trigeminal vascular system (TVS). This study investigated how neuroinflammation induced by systemic lipopolysaccharide (LPS) affects migraine-related nociceptive signaling. Using a chronic migraine model in rats with nitroglycerin (NTG), we compared prenatal and acute postnatal LPS administration. Rats with prenatal LPS exhibited lower mechanical thresholds and enhanced allodynia and photophobia after NTG. Acute LPS also increased allodynia, but not photophobia. Both LPS groups showed increased mast cell degranulation in the dura mater. Plasma CGRP after NTG administration was elevated in the acute LPS group. Electrophysiology revealed enhanced trigeminal afferent responses to serotonin in both acutely and prenatally LPS-treated rats. Calcium imaging demonstrated increased neuronal responses to serotonin and capsaicin, suggesting an upregulation of serotonin and TRPV1 receptors. Our findings show that LPS-induced neuroinflammation, whether prenatal or acute, promotes sensitization of peripheral and central nociceptive pathways, involving serotoninergic mechanisms.

Indexed as

HyperalgesiaLipopolysaccharidesMigraine DisordersNeuroinflammatory DiseasesPhotophobiaSerotoninTrigeminal NerveAnimalsCalcitonin Gene-Related PeptideDisease Models, AnimalFemaleMaleNitroglycerinPregnancyRatsRats, Sprague-DawleyCalcitonin Gene-Related PeptideLipopolysaccharidesNitroglycerinSerotoninTRPV Cation ChannelsCGRPLPSmast cellmechanical allodyniamigraineneuroinflammationphotophobiasensitizationtrigeminal system

Identifiers

PMID41465411
PMCPMC12732506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.