Single-Cell and Bulk RNA Sequencing Reveal SPINK1 and TIMP1 as Epithelial Cell Marker Genes Linked to Colorectal Cancer Survival and Tumor Immune Microenvironment Profiles.

Noor N Al-Bzour, Zaid Nassar Abu-Rjai', Ayah N Al-Bzour, Abdulrahman Qasaymeh, Anwaar Saeed, Azhar Saeed

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Noor N Al-BzourDepartment of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0009-0008-0308-9182

Zaid Nassar Abu-Rjai'Department of Medicine, Yarmouk University, Irbid 21163, Jordan.

Ayah N Al-BzourDepartment of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.ORCID 0000-0001-8216-0400

Abdulrahman QasaymehDepartment of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Anwaar SaeedDepartment of Medicine, Division of Hematology and Oncology, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA 15219, USA.

Azhar SaeedDepartment of Pathology and Laboratory Medicine, University of Vermont Medical Center, Burlington, VT 05401, USA.ORCID 0000-0002-8421-4465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is a major cause of cancer death, with the tumor microenvironment and gene expression influencing outcomes. Identifying survival-associated epithelial marker genes (EMGs) may improve prognosis and guide therapy. We obtained single-cell RNA-sequencing (scRNA-seq) data from CRC patients (

Indexed as

Biomarkers, TumorColorectal NeoplasmsEpithelial CellsTissue Inhibitor of Metalloproteinase-1Trypsin Inhibitor, Kazal PancreaticTumor MicroenvironmentAgedFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisSequence Analysis, RNASingle-Cell AnalysisBiomarkers, TumorSPINK1 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1Trypsin Inhibitor, Kazal Pancreaticcolorectal cancerepithelial cells biomarkerssingle-cell analysissurvivaltumor immune microenvironment

Identifiers

PMID41465391

DOI10.3390/ijms262411964

PMCPMC12733225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.