Exploring the Molecular Mechanism of Hepatic Dysfunction Among Workers Exposed to Nickel and Chromium in Electroplating.

Mona Abdallah Ramadan, Marwa Abdelgwad, Reem T Atawia, Amira M Badr, Eman Mahmoud Khalifa, Layla A Alkharashi, Rateba Said Mohammed

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mona Abdallah RamadanOccupational and Environmental Medicine Department, Faculty of Medicine, Cairo University, Al Giza 12613, Egypt.ORCID 0000-0002-1065-9824

Marwa AbdelgwadMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Al Giza 12613, Egypt.ORCID 0000-0003-3719-6687

Reem T AtawiaDepartment of Pharmaceutical Sciences, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK 73096, USA.

Amira M BadrDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11415, Saudi Arabia.ORCID 0000-0003-3983-868X

Eman Mahmoud KhalifaOccupational and Environmental Medicine Department, Faculty of Medicine, Cairo University, Al Giza 12613, Egypt.ORCID 0000-0002-3814-7142

Layla A AlkharashiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11415, Saudi Arabia.ORCID 0000-0003-3171-771X

Rateba Said MohammedOccupational and Environmental Medicine Department, Faculty of Medicine, Cairo University, Al Giza 12613, Egypt.ORCID 0000-0001-7697-0001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to nickel (Ni) and chromium (Cr) in environmental and occupational settings appears to be inevitable and significantly affects the liver, the principal organ responsible for their metabolic processes. This research aimed to assess the functional integrity of the liver and the molecular mechanisms underlying hepatic damage in employees exposed to Ni and Cr at work. A cross-sectional investigation was implemented with 86 non-smoking male employees working in a metallurgical factory. Serum Cr, Ni, liver function tests, oxidative and inflammatory indicators, and

Indexed as

ChromiumElectroplatingLiverNickelOccupational ExposureAdultCross-Sectional StudiesHumansKelch-Like ECH-Associated Protein 1Liver Function TestsMaleMicroRNAsMiddle AgedNF-E2-Related Factor 2Oxidative StressChromiumKEAP1 protein, humanKelch-Like ECH-Associated Protein 1MicroRNAsNFE2L2 protein, humanNF-E2-Related Factor 2Nickelchromiumelectroplating workershepatotoxicityKeap-1/Nrf2nickeloxidative stress

Identifiers

PMID41465380

DOI10.3390/ijms262411954

PMCPMC12732974

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.