Evidence map›Paper›PMID 41465373›Full record

ArticleInternational journal of molecular sciences2025

Generation of a

Cynthia Rodríguez-Nava, Karen Cortés-Sarabia, Lidia Riaño-Umbarila, Baltazar Becerril-Luján, Yolanda Medina-Flores, Olga Mata-Ruíz, Lourdes Lloret-Sánchez, Berenice Illades-Aguiar, Luz Del Carmen Alarcón-Romero, Carlos Ortuño-Pineda

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cynthia Rodríguez-NavaLaboratorio de Investigación en Citopatología e Histoquímica, Universidad Autónoma de Guerrero, Chilpancingo 39086, Mexico.
Karen Cortés-SarabiaLaboratorio de Investigación en Inmunobiología y Diagnóstico Molecular, Universidad Autónoma de Guerrero, Chilpancingo 39086, Mexico.ORCID 0000-0002-4405-2297
Lidia Riaño-UmbarilaInvestigadora por México, Secretaría de Ciencia, Humanidades, Tecnología e Innovación, Cuernavaca 62210, Mexico.ORCID 0000-0002-2531-9232
Baltazar Becerril-LujánDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca 62210, Mexico.
Yolanda Medina-FloresLaboratorio de Anticuerpos Monoclonales, Departamento de Biología Molecular y Validación de Técnicas, Instituto de Diagnóstico y Referencia Epidemiológico "Dr. Manuel Martínez Báez" (InDRE), Mexico City 01480, Mexico.
Olga Mata-RuízLaboratorio de Anticuerpos Monoclonales, Departamento de Biología Molecular y Validación de Técnicas, Instituto de Diagnóstico y Referencia Epidemiológico "Dr. Manuel Martínez Báez" (InDRE), Mexico City 01480, Mexico.
Lourdes Lloret-SánchezLaboratorio de Anticuerpos Monoclonales, Departamento de Biología Molecular y Validación de Técnicas, Instituto de Diagnóstico y Referencia Epidemiológico "Dr. Manuel Martínez Báez" (InDRE), Mexico City 01480, Mexico.ORCID 0000-0002-5393-2894
Berenice Illades-AguiarLaboratorio de Investigación en Biomedicina Molecular, Universidad Autónoma de Guerrero, Chilpancingo 39086, Mexico.ORCID 0000-0003-3937-335X
Luz Del Carmen Alarcón-RomeroLaboratorio de Investigación en Citopatología e Histoquímica, Universidad Autónoma de Guerrero, Chilpancingo 39086, Mexico.ORCID 0000-0002-2074-4889
Carlos Ortuño-PinedaLaboratorio de Ácidos Nucleicos y Proteínas, Universidad Autónoma de Guerrero, Chilpancingo 39086, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer (CC) can be prevented through continuous screening and the timely detection of cervical intraepithelial neoplasia (CIN) using immunohistochemistry techniques to identify biomarker expressions. In a previous study, we proposed nuclear REST loss as a biomarker in precancerous lesions and CC; however, no validated antibodies are available for detecting REST in cytology or cervical tissues. Although we have developed an IgM-type anti-REST monoclonal antibody capable of detecting REST in liquid-based cytology cells, it was not useful for the detection of REST in cervical tissues by immunohistochemistry. The main objective of this study is to generate single-chain variable fragments (

Indexed as

Carcinoma, Squamous CellImmunoglobulin MPrecancerous ConditionsRepressor ProteinsSingle-Chain AntibodiesUterine Cervical DysplasiaUterine Cervical NeoplasmsAnimalsBiomarkers, TumorFemaleHumansHybridomasImmunohistochemistryMiceBiomarkers, TumorImmunoglobulin MRepressor ProteinsSingle-Chain AntibodiesCervical cancerimmunocytochemistryRESTscFv

Identifiers

PMID41465373
PMCPMC12732971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.