Evidence map›Paper›PMID 41465371›Full record

ArticleInternational journal of molecular sciences2025

Assessments of Wnt/JAK-STAT Signaling Pathway in Relation to Sfrp5 Among Patients with Cardiac Diseases.

Mohammed H Hassan, Sawsan M A Abuhamdah, Omyma Ashraf Hasan, Mohammed Ak, Asmaa Nafady, Nehal Ashraf Zaki, Marwa Abdelhady, Rana Toghan, Tahia H Saleem

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohammed H HassanDepartment of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Sawsan M A AbuhamdahDepartment of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman 11942, Jordan.
Omyma Ashraf HasanDepartment of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Mohammed AkDepartment of Internal Medicine, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Asmaa NafadyDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Nehal Ashraf ZakiDepartment of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Marwa AbdelhadyDepartment of Internal Medicine, Luxor University, Luxor 85951, Egypt.
Rana ToghanDepartment of Medical Physiology, Faculty of Medicine, Qena University, Qena 83523, Egypt.
Tahia H SaleemDepartment of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Assuit University, Assuit 71515, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases have become a leading global health burden, with rising mortality worldwide. WNT and JAK/STAT have been highlighted as emerging biomarkers in cardiovascular disease pathogenesis. This study assessed the Wnt/JAK-STAT signaling pathway in relation to SFRP5 and genetic polymorphisms in cardiac patients. This prospective case-control study included 100 patients with various cardiac diseases (IHD, valvular heart disease, HF, cardiomyopathy, and arrhythmia) and 50 matched healthy controls. Clinical and echocardiographic assessments were performed. Plasma SFRP5, Wnt5a, and JAK levels were measured using ELISA; STAT5A expression by flow cytometry; and SFRP5 (rs780369540) gene polymorphism by TaqMan real-time PCR were also performed in all participants. Cardiac patients showed significantly higher median BMI (33 vs. 28.5 kg/m

Indexed as

Adaptor Proteins, Signal TransducingEye ProteinsHeart DiseasesJanus KinasesMembrane ProteinsWnt Signaling PathwayAgedBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideProspective StudiesSecreted Frizzled-Related ProteinsAdaptor Proteins, Signal TransducingBiomarkersEye ProteinsJanus KinasesMembrane ProteinsSecreted Frizzled-Related ProteinsSFRP5 protein, humanSTAT5A protein, humanSTAT5 Transcription FactorTumor Suppressor ProteinsWnt-5a ProteinWNT5A protein, humancardiovascular diseaseJAK-STAT pathwaymolecular biomarkersSFRP5 polymorphismWnt signaling

Identifiers

PMID41465371
PMCPMC12732818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.