The Proteome of Acute Muscle Pain: Observations from Acute Hypertonic-Saline-Induced Pain in Humans.

Pauline Jubin, Marie Amigo, Daniel Boulton, David A Mahns, Saad S Nagi, James S Dunn

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pauline JubinSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.ORCID 0000-0002-1087-257X

Marie AmigoSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.ORCID 0009-0008-3626-0273

Daniel BoultonSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.ORCID 0000-0002-8569-2469

David A MahnsSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.ORCID 0000-0003-2131-9638

Saad S NagiDepartment of Biomedical and Clinical Sciences, Linköping University, 582 25 Linköping, Sweden.ORCID 0000-0001-8773-8232

James S DunnSchool of Medicine, Western Sydney University, Campbelltown, NSW 2560, Australia.ORCID 0000-0002-6282-2996

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the widespread use of experimental acute pain models, little exploration has been undertaken on the acute pain proteome in humans. We resolved to explore molecular alterations evoked by hypertonic saline (HS)-induced acute muscle pain and to map the spread of mechanical hyperalgesia. This study used a two-cohort design in healthy participants. Cohort one (

Indexed as

Acute PainMyalgiaProteomeAdultCytokinesFemaleHumansHyperalgesiaMaleProteomicsSaline Solution, HypertonicYoung AdultCytokinesProteomeSaline Solution, Hypertonicacute pain proteomeallodyniamechanical hyperalgesiamolecular signalingmuscle painnociceptionpain mechanisms

Identifiers

PMID41465347

DOI10.3390/ijms262411922

PMCPMC12732361

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.