Deciphering the Role of ADAMTS6 in the Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells.

Kirill V Odarenko, Anastasiya M Matveeva, Grigory A Stepanov, Marina A Zenkova, Andrey V Markov

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Kirill V OdarenkoInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0003-1092-0014

Anastasiya M MatveevaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Grigory A StepanovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0003-3393-3192

Marina A ZenkovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0003-4044-1049

Andrey V MarkovInstitute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0001-7569-9555

Funding

Russian Science Foundation 19-74-30011Russian state-funded project for ICBFM SB RAS 125012300659-6Russian state-funded project for ICBFM SB RAS 125012300660-2

6 · The paper itself

Abstract

A disintegrin and metalloproteinase with thrombospondin motifs 6 (ADAMTS6) is an extracellular matrix (ECM) protease that promotes the invasion of lung adenocarcinoma (LUAD) cells. Herein, we investigate its role in epithelial-mesenchymal transition (EMT), a process that drives metastasis and drug resistance in LUAD. Re-analysis of microarray and RNA sequencing data from LUAD cells revealed that during EMT, TGF-β1 increased

Indexed as

ADAMTS ProteinsAdenocarcinoma of LungEpithelial-Mesenchymal TransitionLung NeoplasmsA549 CellsCell Line, TumorCell MovementDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansNuclear ProteinsSignal TransductionTransforming Growth Factor beta1Twist-Related Protein 1ADAMTS ProteinsNuclear ProteinsTransforming Growth Factor beta1TWIST1 protein, humanTwist-Related Protein 1ADAMTSdrug resistanceEMTlung cancermetastasis

Identifiers

PMID41465277

DOI10.3390/ijms262411850

PMCPMC12732811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.