Evidence map›Paper›PMID 41465245›Full record

ArticleInternational journal of molecular sciences2025

Spatial Multi-Omics Analysis of the Qianqiu Goat Gut Microbiome and Metabolome.

Panpan Guo, Wenjuan Qin, Wencheng Song, Hongquan Chen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Panpan GuoSchool of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wenjuan QinSchool of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.
Wencheng SongHefei Institute of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
Hongquan ChenSchool of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China.ORCID 0000-0002-8426-0672

Funding

National Natural Science Foundation of China Natural 22576206Wanjiang Emerging Industry Technology Development Center 2024 Industrialization Project WJ24CYHXM06
6 · The paper itself

Abstract

This study profiled the rumen (RM), small intestine (SI), and large intestine (LI) of 24 samples collected from eight 6-month-old Qianqiu goats (body weight 28.40 ± 1.80 kg), with the samples equally divided into three groups. A combination of methods was used, including 16S rRNA sequencing, untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, and weighted gene co-expression network analysis-based module detection (WGCNA) with network integration. An uncommon composition of organisms dominated the SI: the hydrogenotrophic methanogens Methanobrevibacter (SI 24.51%; RM 1.92%; LI 2.19%) and Methanosphaera (SI 0.43%; RM 0.02%; LI 0.02%), together with the acetogen Acetitomaculum (SI 1.58%; RM 0.34%; LI 0.11%), were markedly more abundant compared to the RM or LI. Correlation and pathway analyses indicated that Methanobrevibacter was positively correlated with a steroid-type lipid metabolite (

Indexed as

Gastrointestinal MicrobiomeGoatsMetabolomeMetabolomicsAnimalsMultiomicsRNA, Ribosomal, 16SRumenRNA, Ribosomal, 16Sintegrated analysismetabolomicsmicrobiomeQianqiu goatspatial multi-omics

Identifiers

PMID41465245
PMCPMC12732871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.