Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1-3, and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) but Does Not Alter IL-17 Levels in Whole-Blood Cultures of Patients with Spondyloarthritis.

Borisz Varga, Gergely Toldi, László Vécsei, Yvette Mándi, Attila Balog

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Borisz VargaDepartment of Rheumatology and Immunology, University of Szeged, 6725 Szeged, Hungary.

Gergely ToldiLiggins Institute, University of Auckland, Auckland 1023, New Zealand.ORCID 0000-0003-0178-1243

László VécseiDepartment of Neurology, University of Szeged, 6725 Szeged, Hungary.

Yvette MándiDepartment of Medical Microbiology, University of Szeged, 6720 Szeged, Hungary.ORCID 0000-0003-4729-2445

Attila BalogDepartment of Rheumatology and Immunology, University of Szeged, 6725 Szeged, Hungary.

Funding

Hungarian Association of Rheumatology 2024. MRE/KP/I/3

6 · The paper itself

Abstract

Kynurenic acid (KYNA) has recognized anti-inflammatory and immunosuppressive properties. Previous studies demonstrated that KYNA reduces TNF-α, S100A12, S100A8/9, and α-defensin production while increasing tumor necrosis factor-stimulated gene-6 protein (TSG-6) levels in rheumatoid arthritis. This study evaluated a synthetic KYNA analog's effects on TNF-α, S100A8/9, S100A12, α-defensin, and interleukin-17 (IL-17) production and TSG-6 expression in ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Peripheral blood mononuclear cells from 54 AS and 38 PsA patients and 11 healthy controls were stimulated with heat-inactivated

Indexed as

Cell Adhesion MoleculesInterleukin-17Kynurenic AcidSpondylitis, AnkylosingTumor Necrosis Factor-alphaAdultalpha-DefensinsCalgranulin ACalgranulin BFemaleHumansLeukocyte L1 Antigen ComplexLeukocytes, MononuclearMaleMiddle AgedS100A12 Proteinalpha-DefensinsCalgranulin ACalgranulin BCell Adhesion MoleculesInterleukin-17Kynurenic AcidLeukocyte L1 Antigen ComplexS100A12 ProteinS100A12 protein, humanS100A8 protein, humanS100A9 protein, humanTNFAIP6 protein, humanTumor Necrosis Factor-alphaalpfa-defensincalgranulinsHNP1–3interleukine-17kynurenic acidkynureninespondyloarthritisTNFα-stimulated gene-6TSG-6

Identifiers

PMID41465233

DOI10.3390/ijms262411801

PMCPMC12733208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.