Evidence map›Paper›PMID 41465231›Full record

ArticleInternational journal of molecular sciences2025

Alginate-Based Microparticles Containing Albumin and Doxorubicin: Nanoarchitectonics and Characterization.

Magdalena Kędzierska, Katarzyna Sala, Dominika Wanat, Dominika Wroniak, Magdalena Bańkosz, Piotr Potemski, Bożena Tyliszczak

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Magdalena KędzierskaDepartment of Clinical Oncology, Central Clinical Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland.
Katarzyna SalaDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, CUT Doctoral School, Cracow University of Technology, 37 Jana Pawla II Av., 31-864 Krakow, Poland.ORCID 0009-0008-5640-0261
Dominika WanatDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, CUT Doctoral School, Cracow University of Technology, 37 Jana Pawla II Av., 31-864 Krakow, Poland.
Dominika WroniakDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawla II Av., 31-864 Krakow, Poland.
Magdalena BańkoszDepartment of Materials Engineering, Faculty of Materials Engineering and Physics, CUT Doctoral School, Cracow University of Technology, 37 Jana Pawla II Av., 31-864 Krakow, Poland.ORCID 0000-0002-8016-7104
Piotr PotemskiDepartment of Clinical Oncology, Central Clinical Hospital of the Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland.ORCID 0000-0001-7573-7347
Bożena TyliszczakCenter for Advanced Functional Materials and Biomimetic Technologies, Warszawska 24, 31-155 Cracow, Poland.ORCID 0000-0002-2761-6185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alginate-based microcapsules have gained considerable attention as drug delivery systems due to their biocompatibility, biodegradability, and ability to encapsulate therapeutic agents. In this study, microcapsules were synthesized by crosslinking with calcium ions, with albumin serving as a carrier for doxorubicin. The goal was to develop a stable system capable of controlled drug release under physiological conditions, with potential applications in cancer therapy. Sodium alginate was used as a base polymer, which formed a stable matrix after crosslinking with calcium ions. The resulting microcapsules showed a uniform size distribution in the microscale range. Analyses confirmed their stability in simulated physiological environments with minimal degradation. Observations revealed a homogeneous structure of the microcapsules, while incubation studies confirmed controlled drug release triggered by pH changes. The results indicate that alginate-albumin microcapsules can serve as an effective platform for drug delivery, especially in cancer therapy and other biomedical applications.

Indexed as

AlbuminsAlginatesAntibiotics, AntineoplasticDoxorubicinDrug CarriersBody FluidsCapsulesDrug StabilityNanotechnologyAlbuminsAlginatesAntibiotics, AntineoplasticCapsulesDoxorubicinDrug Carriersalginate microcapsulesbiomedical applicationsdrug delivery

Identifiers

PMID41465231
PMCPMC12732384

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.