Adipose-Derived Mesenchymal Stem Cells Improve Acute Liver Injury: A Mechanistic Study Based on the TLR4/MyD88/NF-κB Pathway.

Zhongfa Wang, Minjuan Li, Xingxing Yan, Yanchen Liu, Pengkun Yang, Wenzhong Liu, Weijun Guan

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhongfa WangDepartment of Animal Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.ORCID 0009-0006-7526-2285

Minjuan LiDepartment of Animal Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Xingxing YanDepartment of Animal Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Yanchen LiuDepartment of Animal Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Pengkun YangDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science, Shanxi Agricultural University, Jinzhong 030600, China.ORCID 0009-0005-4536-9391

Wenzhong LiuDepartment of Animal Genetics, Breeding and Reproduction, College of Animal Science, Shanxi Agricultural University, Jinzhong 030600, China.

Weijun GuanDepartment of Animal Genetic Resources, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Funding

National Key Research and Development Program of China 2021YFD1200303Research on the preservation of somatic cells and stem cells from domestic animals and their biological characteristics NGCDAR-IAS202507

6 · The paper itself

Abstract

Acute liver injury (ALI) involves complex pathogenesis and lacks effective clinical therapies. Although mesenchymal stem cells (MSCs) demonstrate therapeutic potential, the role and mechanisms of adipose-derived mesenchymal stem cells (ADSCs) from Luopan Mountain pigs remain unclear. This study assessed the therapeutic potential of Luopan Mountain pig ADSCs in a D-GalN-induced rat model of ALI and investigated its association with the TLR4/MyD88/NF-κB axis. Results showed that ADSCs transplantation significantly improved liver function (by reducing ALT, AST, and TBIL levels and increasing ALB levels) and alleviated histopathological damage in liver tissue. Mechanistically, ADSCs conferred multi-faceted hepatoprotection via inhibition of the TLR4/MyD88/NF-κB axis, synergistically downregulating proinflammatory factors (TNF-α, IL-1β, IL-6, IL-8), enhancing antioxidant enzyme activity (SOD, GSH-PX), and promoting the expression of the hepatocyte regeneration marker Ki67. We demonstrate for the first time that Luopan Mountain pig ADSCs synergistically repair acute liver injury by inhibiting the TLR4/MyD88/NF-κB pathway, offering novel insights for cell therapy in ALI.

Indexed as

Adipose TissueMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMyeloid Differentiation Factor 88NF-kappa BSignal TransductionToll-Like Receptor 4AnimalsDisease Models, AnimalLiverMaleRatsRats, Sprague-DawleySwineMyd88 protein, ratMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, ratToll-Like Receptor 4ADSCsanti-inflammatoryantioxidantliver regenerationLuopan Mountain pigTLR4/MyD88/NF-κB

Identifiers

PMID41465230

DOI10.3390/ijms262411798

PMCPMC12732611

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.