Evidence map›Paper›PMID 41465227›Full record

ArticleInternational journal of molecular sciences2025

Disease-Free Survival of Patients with Stage II Stroma-Rich Colorectal Adenocarcinomas with Microsatellite Stability.

Ángel Romo-Navarro, Juan Ruiz Martín, Irene García-Camacha Gutiérrez, Mariano Amo-Salas, María Recuero Pradillo, César Sánchez-Muñoz, Cristina María Murillo Lázaro, Esperanza Carabias López, Raquel Sánchez Simón, Carlos Quimbayo-Arcila and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ángel Romo-NavarroDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.ORCID 0000-0002-7094-8484
Juan Ruiz MartínDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.ORCID 0000-0002-7372-0661
Irene García-Camacha GutiérrezDepartment of Mathematics, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0003-3296-056X
Mariano Amo-SalasDepartment of Mathematics, University of Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0002-0956-2531
María Recuero PradilloDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.ORCID 0000-0002-3961-7687
César Sánchez-MuñozDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.ORCID 0009-0002-0751-6176
Cristina María Murillo LázaroDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.
Esperanza Carabias LópezDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.
Raquel Sánchez SimónDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.
Carlos Quimbayo-ArcilaDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.
Yasmina Hernández MartínHospital Nacional de Parapléjicos, 45071 Toledo, Spain.ORCID 0000-0002-9881-5974
María-Sonsoles Opazo RodríguezDepartment of Pathology, Complejo Hospitalario Universitario de Toledo, 45007 Toledo, Spain.
Yolanda Campos-MartínDepartment of Inorganic Chemistry, Organic Chemistry and Biochemistry, Faculty of Environmental Sciences and Biochemistry, University of Castilla-La Mancha, 45004 Toledo, Spain.ORCID 0000-0001-9686-7036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 25% of stage II colorectal adenocarcinomas recur within the first five years after diagnosis. The assessment of the stromal percentage, recently incorporated into the TNM classification system, may represent a particularly relevant predictive factor for recurrence in cases with microsatellite stability. We evaluated disease-free survival (DFS) in an independent retrospective cohort, measured the stromal percentage across the entire invasive front of the tumor, and assessed the interobserver agreement of this measurement method. Among 131 cases, 16 (12.2%) showed a high stromal percentage and 115 (87.8%) a low one. A high stromal percentage was associated with high-grade budding (

Indexed as

AdenocarcinomaColorectal NeoplasmsMicrosatellite InstabilityAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesStromal Cellscolorectal cancermesenchymalstage IIstroma

Identifiers

PMID41465227
PMCPMC12732471

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.