Evidence map›Paper›PMID 41465214›Full record

ArticleInternational journal of molecular sciences2025

Enhancing Cytosolic Internalization of [

Erika Azorín-Vega, Daniel García-Arce, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Diana Trujillo-Benítez, Abraham Vidal-Limon, Griselda Rodríguez-Martínez, María Luisa Durán-Pastén, Laura Meléndez-Alafort, Guillermina Ferro-Flores

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erika Azorín-VegaDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Mexico.ORCID 0000-0002-7520-461X
Daniel García-ArceDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Mexico.
Myrna Luna-GutiérrezDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Mexico.ORCID 0000-0002-4082-3816
Blanca Ocampo-GarcíaDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Mexico.ORCID 0000-0002-5831-8412
Diana Trujillo-BenítezDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Mexico.
Abraham Vidal-LimonNetwork for Advanced Molecular Studies, Instituto de Ecología A.C., Xalapa-Enríquez 91070, Mexico.ORCID 0000-0001-5674-7881
Griselda Rodríguez-MartínezRespiratory Pathogens Research Laboratory, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.
María Luisa Durán-PasténChannelopathies National Laboratory, Cellular Physiology Institute, UNAM, Mexico City 04510, Mexico.
Laura Meléndez-AlafortImmunology and Molecular Oncology Diagnostics Unit, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0003-0701-3616
Guillermina Ferro-FloresDepartment of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Mexico.ORCID 0000-0003-0296-7605

Funding

International Atomic Energy Agency CRP-F22078Italian Ministry of Health No. 5x1000 (2019) project "DECURTA"Secretary of Science, Humanities, Technology, and Innovation (SECIHTI, Mexico) CBF-2025-I-3583
6 · The paper itself

Abstract

Castration-resistant prostate cancer presents radiotherapeutic challenges, especially in optimizing the cytosolic internalization of therapeutic radiopharmaceuticals. This research aimed to design and evaluate in vitro, a new dimeric radiopharmaceutical, [

Indexed as

CytosolHeat-Shock ProteinsLutetiumProstatic NeoplasmsRadioisotopesRadiopharmaceuticalsAntigens, SurfaceCell Line, TumorEndoplasmic Reticulum Chaperone BiPGlutamate Carboxypeptidase IIHumansMaleMolecular Docking SimulationAntigens, SurfaceEndoplasmic Reticulum Chaperone BiPFOLH1 protein, humanGlutamate Carboxypeptidase IIHeat-Shock ProteinsHSPA5 protein, humanLutetiumLutetium-177RadioisotopesRadiopharmaceuticals[177Lu]Lu–iPSMAGRP78 inhibitorlutetium-177PSMA inhibitor

Identifiers

PMID41465214
PMCPMC12733166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.