Evidence map›Paper›PMID 41465204›Full record

ArticleInternational journal of molecular sciences2025

Intratumoral Heterogeneity of MAGED4 Expression in Oral Squamous Cell Carcinoma: Epigenetic Mechanisms and Therapeutic Implications.

Huan Xie, Feng Li, Xiaoqiong Zou, Xiaoqing Yu, Sheng Zhang, Yanjing Wang, Weixia Nong, Limin Xie, Yi Wang, Bin Luo and 2 more

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Huan XieDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.ORCID 0009-0000-6787-7630
Feng LiDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Xiaoqiong ZouDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Xiaoqing YuDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Sheng ZhangDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Yanjing WangDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Weixia NongDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Limin XieGeneral Practice School, Guangxi Medical University, Nanning 530021, China.
Yi WangGeneral Practice School, Guangxi Medical University, Nanning 530021, China.
Bin LuoDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Xiaoxun XieDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.
Qingmei ZhangDepartment of Histology and Embryology, School of Basic Medicine Science, Guangxi Medical University, Nanning 530021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intratumoral heterogeneity poses significant challenges to the efficacy of cancer immunotherapy. Melanoma-associated antigen D4 (MAGED4) has been proposed as a potential immunotherapeutic target in oral squamous cell carcinoma (OSCC). This study aims to investigate the expression of MAGED4, focusing on its intratumoral expression heterogeneity and the underlying epigenetic regulation mechanism. Utilizing public online databases, immunohistochemical analyses of clinical specimens, and single-cell RNA sequencing data, we found that MAGED4 was overexpressed with significant intratumoral heterogeneity in OSCC tissues. Methylation-promoter luciferase reporter assays revealed that

Indexed as

Carcinoma, Squamous CellEpigenesis, GeneticGene Expression Regulation, NeoplasticMouth NeoplasmsNeoplasm ProteinsAcetylationCell Line, TumorDecitabineDNA MethylationHistone Deacetylase InhibitorsHistonesHumansHydroxamic AcidsMalePromoter Regions, GeneticValproic AcidDecitabineHistone Deacetylase InhibitorsHistonesHydroxamic AcidsNeoplasm Proteinstrichostatin AValproic AcidDNA methylationhistone acetylationintratumoral heterogeneityMAGED4OSCC

Identifiers

PMID41465204
PMCPMC12732915

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.