Evidence map›Paper›PMID 41465201›Full record

ArticleInternational journal of molecular sciences2025

Tuning Photothermal Properties of Graphene Oxide by Heteroatom Doping for Cancer Elimination: Experimental and DFT Study.

Alan Miranda, Mateo Salazar, D G Larrude, Leandro Seixas, Alexis Debut, Myriam González, Karina J Lagos, Orlando Campaña, Miryan Rosita Rivera, Maria Paulina Romero

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dual modulation of intracellular CaJournal of molecular histology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alan MirandaEscuela Politécnica Nacional, Quito 170525, Ecuador.
Mateo SalazarLaboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador (PUCE), Quito 170143, Ecuador.ORCID 0000-0002-1225-7140
D G LarrudeGraphene and Nano-Materials Research Center-MackGraphe, Mackenzie Presbyterian University, São Paulo 01302-907, Brazil.ORCID 0000-0001-8126-5876
Leandro SeixasInstituto de Fisica Teórica, Universidade Estadual Paulista-Júlio de Mesquita Filho, São Paulo 01140-907, Brazil.ORCID 0000-0001-7420-0708
Alexis DebutCentro de Nanociencia y Nanotecnología, Universidad de Las Fuerzas Armadas ESPE, Sangolquí 171103, Ecuador.ORCID 0000-0002-8269-7619
Myriam GonzálezEscuela Politécnica Nacional, Quito 170525, Ecuador.ORCID 0000-0001-5813-9863
Karina J LagosEscuela Politécnica Nacional, Quito 170525, Ecuador.
Orlando CampañaEscuela Politécnica Nacional, Quito 170525, Ecuador.
Miryan Rosita RiveraLaboratorio de Investigación en Citogenética y Biomoléculas de Anfibios (LICBA), Centro de Investigación para la Salud en América Latina (CISeAL), Facultad de Ciencias Exactas y Naturales, Pontificia Universidad Católica del Ecuador (PUCE), Quito 170143, Ecuador.ORCID 0000-0002-9944-7130
Maria Paulina RomeroEscuela Politécnica Nacional, Quito 170525, Ecuador.ORCID 0000-0002-3524-3905

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer poses a global challenge, affecting millions of people and placing a significant burden on families and healthcare systems. Chemotherapy, radiotherapy, hormone therapy, and immunotherapy are commonly used for cancer treatment; their side effects can be severe. Photothermal therapy (PTT) has emerged as a promising alternative due to its minimal invasiveness and high efficiency. In this study, graphene oxide (GO) was synthesized and functionalized to obtain nitrogen-doped graphene oxide (NGO) and boron-doped graphene oxide (BGO) via a hydrothermal process, aiming to use them as photoactive agents (PAs) in PTT. Atomic force microscopy (AFM) analysis revealed that GO, BGO, and NGO exhibit monolayer atomic structures. Spectroscopic analyses confirmed the presence of oxygen and carbon in all samples, along with successful boron and nitrogen doping in BGO and NGO, respectively. Cytotoxicity assays yielded half-maximal inhibitory concentrations (IC

Indexed as

Antineoplastic AgentsGraphiteNeoplasmsPhotothermal TherapyBoronCell Line, TumorDensity Functional TheoryHumansMicroscopy, Atomic ForceNitrogenAntineoplastic AgentsBorongraphene oxideGraphiteNitrogencancercomputational simulationsdopinggraphene oxidephotosensitizing agentsphotothermal therapy

Identifiers

PMID41465201
PMCPMC12732777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.