Evidence map›Paper›PMID 41465175›Full record

ReviewGenes2025

Functional Interpretation of a Novel Homozygous METTL5 Variant Associated with ADHD and Neurodevelopmental Abnormalities: A Case Report and Literature Review.

Sheema Hashem, Saba F Elhag, Ajaz A Bhat, Waleed Aamer, Aljazi Al-Maraghi, Hala Alhaboub, Dalya Abuthaher, Ammira S Al-Shabeeb Akil, Mohammad Haris, Khalid Fakhro and 2 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sheema HashemCollege of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Doha P.O. Box 5825, Qatar.
Saba F ElhagCollege of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Doha P.O. Box 5825, Qatar.
Ajaz A BhatMetabolic and Mendelian Disorders Clinical Research Program, Precision OMICs Research & Translational Science, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0003-3640-6275
Waleed AamerDepartment of Human Genetics, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0002-1324-3509
Aljazi Al-MaraghiDepartment of Human Genetics, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Hala AlhaboubDepartment of Pediatrics, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0009-0002-8595-8244
Dalya AbuthaherDepartment of Pediatrics, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Ammira S Al-Shabeeb AkilMetabolic and Mendelian Disorders Clinical Research Program, Precision OMICs Research & Translational Science, Sidra Medicine, Doha P.O. Box 26999, Qatar.
Mohammad HarisCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Khalid FakhroDepartment of Human Genetics, Sidra Medicine, Doha P.O. Box 26999, Qatar.ORCID 0000-0002-3150-1276
Georges NemerCollege of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Doha P.O. Box 5825, Qatar.ORCID 0000-0003-2157-5279
Madeeha KamalDepartment of Pediatrics, Sidra Medicine, Doha P.O. Box 26999, Qatar.

Funding

Qatar National Research Fund (QNRF) (NPRP 13S-0121-200129)
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Attention Deficit Disorder with HyperactivityMethyltransferasesNeurodevelopmental DisordersAdolescentFemaleHomozygoteHumansMethyltransferasesattention-deficit/hyperactivity disorderconsanguinityMethyltransferase Like 5microcephalyneurodevelopmental disordernovel variantRNA methylationtrio analysiswhole-genome sequencing

Identifiers

PMID41465175
PMCPMC12733326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.