ArticleGenes2025
Duplication, Divergence and Cardiac Expression of Tropoelastin in Jawed Fishes, Including Tetraploid Rainbow Trout (
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesTropoelastin is a highly hydrophobic extracellular matrix protein responsible for the extensibility and elastic recoil of various organs. The Windkessel effect in blood vessels dampens pressure variations during the cardiac cycle to provide continuous perfusion of tissues, such as the fragile gill capillaries in fish. The teleost-specific whole-genome duplication was followed by structural and functional divergence of the duplicated tropoelastins, of which ElnB confers the uniquely low stiffness of the bulbus arteriosus.
methodsWe have examined the diversity of tropoelastins in all major fish clades by searching for
resultsThe tetraploid salmonid genomes harbor two
conclusionsThe inclusion of tetrapods in the analysis revealed a positive relationship between ventral aortic blood pressure and tropoelastin hydrophobicity.
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