Evidence map›Paper›PMID 41465118›Full record

ArticleGenes2025

TYK2 Deficiency Presenting as Refractory Disseminated BCG/Tuberculosis Infection in a Kazakh Child: A Case Report with Genetic Confirmation.

Nurgul Sikhayeva, Svetlana Volodchenko, Elena Kovzel, Aiganym Toleuzhanova, Aliya Romanova, Gulnar Tortayeva, Yelena Sagandykova, Marina Morenko, Aidos Bolatov, Ilyas Akhmetollayev

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Case Report:Frontiers in pediatrics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nurgul SikhayevaNational Center for Biotechnology, Korgalzhyn Highway 13/5, Astana 010000, Kazakhstan.ORCID 0000-0001-6419-9483
Svetlana Volodchenko"University Medical Center" Corporate Fund, St. Kerey, Zhanibek Khandar Khanov 5/1, Astana 010000, Kazakhstan.ORCID 0000-0002-7577-5172
Elena Kovzel"University Medical Center" Corporate Fund, St. Kerey, Zhanibek Khandar Khanov 5/1, Astana 010000, Kazakhstan.
Aiganym ToleuzhanovaNational Center for Biotechnology, Korgalzhyn Highway 13/5, Astana 010000, Kazakhstan.ORCID 0000-0003-1477-8780
Aliya RomanovaNational Center for Biotechnology, Korgalzhyn Highway 13/5, Astana 010000, Kazakhstan.ORCID 0009-0000-4483-0493
Gulnar Tortayeva"University Medical Center" Corporate Fund, St. Kerey, Zhanibek Khandar Khanov 5/1, Astana 010000, Kazakhstan.
Yelena Sagandykova"University Medical Center" Corporate Fund, St. Kerey, Zhanibek Khandar Khanov 5/1, Astana 010000, Kazakhstan.
Marina MorenkoDepartment of Pediatrics with Courses in Allergology, Immunology, Hematology, and Endocrinology, School of Medicine, "Medical University of Astana" NAO, Beibitshilik Street 49/A, Astana 010000, Kazakhstan.
Aidos BolatovSchool of Medicine, Shenzhen University, 3688 Nanhai Road, Shenzhen 518060, China.ORCID 0000-0002-5390-4623
Ilyas AkhmetollayevNational Center for Biotechnology, Korgalzhyn Highway 13/5, Astana 010000, Kazakhstan.

Funding

This work was supported by Grant AP19678933 from the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP19678933
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

TuberculosisTYK2 KinaseBCG VaccineChildExome SequencingGranulomatous Disease, ChronicHumansKazakhstanBCG VaccineTYK2 KinaseTYK2 protein, humanBCG vaccinechronic granulomatous diseaseKazakhstanprimary immunodeficiencytuberculosisTYK2whole-exome sequencing

Identifiers

PMID41465118
PMCPMC12733241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.