Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Gene Polymorphisms Predict Arterial Stiffness and Serum MGP Levels in Chronic Kidney Disease Patients.

David H Chen, Cees Vermeer, John R Cockcroft, David C Wheeler, Kevin M O'Shaughnessy, Yasmin

Abstract read

In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David H ChenDivision of Experimental Medicine & Immunotherapeutics, University of Cambridge, Cambridge CB2 0QQ, UK.

Cees VermeerCardiovascular Research Institute CARIM, University of Maastricht, 6229 EV Maastricht, The Netherlands.

John R CockcroftCentre for Cardiovascular Research, Innovation and Development, Cardiff Metropolitan University, Cardiff CF5 2YB, UK.

David C WheelerDepartment of Medicine, University College London, Centre for Nephrology Rowland Hill Street, London NW3 2PF, UK.

Kevin M O'ShaughnessyDivision of Experimental Medicine & Immunotherapeutics, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-1476-7566

YasminDivision of Experimental Medicine & Immunotherapeutics, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-5478-7123

Funding

Addenbrooke's Charitable Trust 23/08(B) (F)Kidney Research UK VC1/2002

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Calcium-Binding ProteinsExtracellular Matrix ProteinsPolymorphism, Single NucleotideRenal Insufficiency, ChronicVascular StiffnessVitamin K Epoxide ReductasesAgedFemaleHumansMaleMatrix Gla ProteinMiddle AgedPulse Wave AnalysisVascular CalcificationCalcium-Binding ProteinsExtracellular Matrix ProteinsMatrix Gla ProteinVitamin K Epoxide ReductasesVKORC1 protein, humanarterial stiffnesschronic kidney diseasevascular calcificationVKORC1 gene polymorphisms

Identifiers

PMID41465069

DOI10.3390/genes16121396

PMCPMC12733207

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.