Gut Microbiota and Liver Metabolism Regulation Mediate the Protective Effects of Inactivated Selenium-Enriched Yeast Against Alcohol-Induced Liver Damage in Mice.

Zihua Liang, Xiangchen Zhang, Shiwei Chen, Meiting Wang, Deying Men, Wangxin Liu, Xucong Lv

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Zihua LiangInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.ORCID 0009-0002-5787-8490

Xiangchen ZhangInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.

Shiwei ChenInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.

Meiting WangInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.

Deying MenInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.

Wangxin LiuInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.

Xucong LvInstitute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou 350108, China.ORCID 0000-0002-0594-4284

Funding

Collaborative Innovation Platform Project of Fuzhou-Xiamen-Quanzhou National Independent Innovation Demonstration Zone No. 2024-P-001

6 · The paper itself

Abstract

Inactivated Selenium-enriched yeast (YSe), as an organic source of selenium with multiple physiological activities, has attracted widespread attention. However, its potential to alleviate alcoholic liver injury (ALD) and its underlying mechanisms remain largely unexplored. This study explores the protective effects of inactivated YSe intervention on ALD in mice and clarifies its mechanism of action. The results indicated that, at the same selenium dose, inactivated YSe intervention was superior to inorganic selenium (sodium selenite) in alleviating ALD. Specifically, high-dose inactivated YSe significantly reduced the levels of serum ALT and AST in alcohol-exposed mice (38.69% and 24.67%, respectively), increased the level of HDL-C (16.83%), and effectively improved alcohol-induced lipid metabolism disorders and liver oxidative damage. At the same time, it significantly increased the concentration of short-chain fatty acids (SCFAs) in feces. 16S rRNA sequencing indicates that inactivated YSe intervention enhances the abundance of beneficial flora (such as

Indexed as

alcohol-induced liver damagefunctional food ingredientgut microbiotaliver metabolismprotective effectsselenium-enriched yeast

Identifiers

PMID41464918

DOI10.3390/foods14244209

PMCPMC12732210

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.