Evidence map›Paper›PMID 41464915›Full record

ReviewFoods (Basel, Switzerland)2025

Nature's Cardioprotective Sweetness: A Review of Dates as Functional Food in Hypertension.

Edwin Leopold Jim, Edmond Leonard Jim, Achmad Wildan, Antonello Santini, Fahrul Nurkolis

Abstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Edwin Leopold JimDepartment of Internal Medicine, Royal Taruma Hospital, Jakarta 11470, Indonesia.
Edmond Leonard JimDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Sam Ratulangi University, Manado 95115, Indonesia.ORCID 0000-0001-7069-7198
Achmad WildanDepartment of Agriculture Technology, Universitas Jenderal Soedirman, Banyumas 53122, Indonesia.
Antonello SantiniDepartment of Pharmacy, University of Napoli Federico II, Via Domenico Montesano, 49-8013 Napoli, Italy.ORCID 0000-0001-5505-3327
Fahrul NurkolisMaster of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia.ORCID 0000-0003-2151-0854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dates contain numerous beneficial nutrients and bioactive compounds, including potassium, magnesium, dietary fiber, polyphenols, flavonoids, and essential fatty acids, which contribute to their antihypertensive effects. Mechanistically, these bioactives reduce oxidative stress, lower inflammation, enhance endothelial function through increased nitric oxide bioavailability, and modulate the renin-angiotensin system. Clinical studies demonstrate that regular, moderate consumption of dates can reduce systolic and diastolic blood pressure, improve lipid profiles, and positively regulate inflammatory and oxidative biomarkers without adverse metabolic or glycemic outcomes. Despite promising findings, variability in date cultivars, ripening stages, and limited standardized human trials necessitate further research. Larger, randomized clinical studies across diverse demographics are recommended to establish optimal dosage, confirm mechanisms of action, and assess long-term safety and effectiveness. This review investigates the potential of dates (

Indexed as

anti-inflammatoryantioxidantblood pressurecardiovascular healthclinical trialsdatesfunctional foodhypertensionPhoenix dactyliferapolyphenols

Identifiers

PMID41464915
PMCPMC12731471

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.