Evidence map›Paper›PMID 41463836›Full record

ArticleAnimals : an open access journal from MDPI2025

Monitoring Weaning Stress in Fillies and Colts on a Thoroughbred Breeding Farm by Cortisol and Blood Inflammatory Markers: The Benefits of Gradual Separation and Social Support.

Ömer Deniz, Hüseyin Serkan Erol, René van den Hoven, Ali Cesur Onmaz, Francesca Aragona, Francesco Fazio

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ömer DenizDepartment of Internal Medicine, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37150, Türkiye.ORCID 0000-0002-2981-2032
Hüseyin Serkan ErolDepartment of Biochemistry Balıkesir Türkiye, Faculty of Veterinary Medicine, Balıkesir University, Balıkesir 10100, Türkiye.ORCID 0000-0002-9121-536X
René van den HovenDepartment of Companion Animals and Horses, Equine University Clinic for Internal Medicine and Infectious Diseases, Veterinary University of Vienna, Veterinärplatz 1, A-1210 Vienna, Austria.ORCID 0000-0001-5655-8837
Ali Cesur OnmazDepartment of Internal Medicine, Faculty of Veterinary Medicine, Erciyes University, Kayseri 38280, Türkiye.
Francesca AragonaDepartment of Veterinary Science, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy.ORCID 0000-0003-2097-0808
Francesco FazioDepartment of Veterinary Science, University of Messina, Via Giovanni Palatucci, 98168 Messina, Italy.ORCID 0000-0003-3198-2580

Funding

Kastamonu University KUBAP-01/2024-29
6 · The paper itself

Abstract

Weaning represents a major developmental milestone for foals, especially when 4- to 7-month-old foals are abruptly separated from their dams. Studies have shown that the post-weaning period is associated with physiological and psychological stress, which may affect immune function. The present study aimed to describe and analyze the pattern of blood inflammatory biomarkers related to the innate immune system. A gradual foal-dam separation procedure was chosen, which included post-weaning social buffering by a familiar adult horse. Twelve Thoroughbred foals (six fillies, six colts) aged 4-6 months were enrolled and divided into a colt and a filly group, and after weaning, were kept as such. Blood samples were collected before and up to 7 days after weaning. Serum cortisol and cytokines (IL-2, IL-6, IL-10, TNF-α, IFN-γ) were quantified using equine-specific ELISA kits. Routine descriptive statistics were used to present the data, and inferences were drawn using a two-way repeated measures ANOVA. The level of significance was set at

Indexed as

cortisolcytokinefoalinflammatory biomarkersstressweaning

Identifiers

PMID41463836
PMCPMC12729675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.