ArticleAntibiotics (Basel, Switzerland)2025
CLSM-Guided Imaging to Visualize the Depth of Effective Disinfection in Endodontics.
Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- CLSM-guided imaging provides new insights into position-dependent limitations of endodontic disinfection.Clinical oral investigations · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
BACKGROUND/
objectivesImportant goals of endodontic treatment procedures are to effectively eliminate microorganisms from the root canal system and prevent reinfection. Despite advances in techniques, these goals continue to be difficult to achieve due to the complex anatomy of the root canal system and bacterial invasion into the dentinal tubules of the surrounding root dentin. This pilot study aimed to refine a confocal laser scanning microscopy (CLSM) model with LIVE/DEAD staining to quantitatively assess the depth of effective disinfection by endodontic disinfection measures.
methodsThirty caries-free human teeth underwent standardized chemo-mechanical root canal preparation and were inoculated with
resultsAn average depth of bacterial eradication of 450 µm for conventional and 520 µm for sonically activated irrigation (EDDY) could be observed with significant differences (
conclusionsThe results indicated that sonically activated irrigation (EDDY) provided a more homogeneous (omnidirectional) irrigation pattern compared to conventional irrigation. The study highlights the importance of effective disinfection strategies in endodontics, emphasizing the need for further research on the depth of effective disinfection of endodontic disinfection measures and the optimization of disinfection protocols.
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