Evidence map›Paper›PMID 41463665›Full record

ReviewBioengineering (Basel, Switzerland)2025

Combined Laser Strategies for Scar Treatment: A Comprehensive Review of Synergistic Protocols.

Alessandro Clementi, Giovanni Cannarozzo, Luca Guarino, Elena Zappia, Fortunato Cassalia, Andrea Danese, Marco Gratteri, Annunziata Dattola, Caterina Longo, Steven Paul Nisticò

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Fractional COLasers in medical science · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro ClementiDepartment of Dermatology, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0009-0003-7001-7756
Giovanni CannarozzoDepartment of Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Luca GuarinoDepartment of Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0002-9678-6409
Elena ZappiaDepartment of Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0009-0005-8167-0325
Fortunato CassaliaDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.ORCID 0000-0002-5014-1122
Andrea DaneseUnit of Dermatology, Department of Integrated Medical and General Activity, University of Verona, 37100 Verona, Italy.ORCID 0009-0003-8656-2927
Marco GratteriDepartment of Plastic, Reconstructive and Cosmetic Surgery, Campus Bio-Medico University Hospital, 00185 Rome, Italy.ORCID 0000-0001-7375-1524
Annunziata DattolaDepartment of Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
Caterina LongoDepartment of Dermatology, University of Modena and Reggio Emilia, 41124 Modena, Italy.ORCID 0000-0002-8218-3896
Steven Paul NisticòDepartment of Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-3828-0883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin scars represent a complex therapeutic challenge, with significant functional, aesthetic, and psychological implications. Despite advances in laser therapy, monotherapy has significant limitations, particularly for patients with complex scars with atrophic, hypertrophic, vascular, and pigmentary components. The combined use of multiple laser sources, in sequential or simultaneous mode, allows for the selective targeting of specific tissue components and improves clinical efficacy while maintaining a good safety profile. This narrative review critically analyses the available evidence on combination therapies for atrophic, hypertrophic, keloid, and post-surgical and burn scars. Protocols combining ablative lasers (CO

Indexed as

atrophic scarscombined protocolsfractional CO2 laserhypertrophic and burn scarslaser therapyscar management

Identifiers

PMID41463665
PMCPMC12729350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.