Evidence map›Paper›PMID 41463630›Full record

ReviewBioengineering (Basel, Switzerland)2025

A Comprehensive Review: The Bidirectional Role of Sebum in Skin Health.

Dan Li, Ziyan Zhou, Xiaobin Yang, Qirong Zhang, Jiaming Xu, Christos C Zouboulis, Qi Xiang, Shu Zhang

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
  4. Enhancing Antibacterial Activity ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dan LiGuangdong Provincial Key Laboratory of Pharmaceutical Preparations Research and Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Ziyan ZhouState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China.ORCID 0000-0003-4436-1505
Xiaobin YangBiopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China.ORCID 0000-0003-4208-9771
Qirong ZhangBiopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China.
Jiaming XuShenzhen Yusu Biotechnology Co., Ltd., Shenzhen 518000, China.
Christos C ZouboulisDepartments of Dermatology, Venereology, Allergology and Immunology, Brandenburg Medical School, Staedtisches Klinikum Dessau, Auenweg 38, 06847 Dessau, Germany.ORCID 0000-0003-1646-2608
Qi XiangGuangdong Provincial Key Laboratory of Pharmaceutical Preparations Research and Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.ORCID 0000-0001-9790-5823
Shu ZhangGuangdong Provincial Key Laboratory of Pharmaceutical Preparations Research and Evaluation, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.ORCID 0000-0002-4124-2597

Funding

Guangzhou Science and Technology Program Project 2024A03J0821Guangzhou Science and Technology Program Project 2024B03J1322
6 · The paper itself

Abstract

Sebum plays a dual role in skin homeostasis, maintaining barrier function and providing antimicrobial defense. However, its dysregulation drives the pathophysiology of common skin diseases. This review explains that abnormal sebum secretion promotes acne vulgaris by inducing follicular occlusion and

Indexed as

acne vulgarisbidirectional role of sebumdry skinmolecular mechanismoily skinsebaceous glands

Identifiers

PMID41463630
PMCPMC12729757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.