Evidence map›Paper›PMID 41463605›Full record

ArticleBioengineering (Basel, Switzerland)2025

Comparative Analysis of Two Measurement Modalities for Ex Vivo Analysis of Corneal Stiffness in Porcine Corneas.

Sophia A Reifeltshammer, Hannah Seferovic, Malavika H Nambiar, Philippe Büchler, Theo G Seiler, Jascha Wendelstein, Matthias Bolz, Peter Hinterdorfer, Yoo Jin Oh, Isaak Fischinger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophia A ReifeltshammerDepartment of Ophthalmology and Optometry, Kepler University Clinic, 4020 Linz, Austria.ORCID 0000-0002-3919-0249
Hannah SeferovicInstitute of Biophysics, Johannes Kepler University, 4020 Linz, Austria.ORCID 0000-0002-8551-8321
Malavika H NambiarARTORG Center for Biomedical Engineering Research, University of Bern, 3011 Bern, Switzerland.
Philippe BüchlerARTORG Center for Biomedical Engineering Research, University of Bern, 3011 Bern, Switzerland.ORCID 0000-0002-8390-4827
Theo G SeilerARTORG Center for Biomedical Engineering Research, University of Bern, 3011 Bern, Switzerland.
Jascha WendelsteinDepartment of Ophthalmology, Ludwig-Maximilians-University Munich, 80539 Munich, Germany.ORCID 0000-0003-4145-2559
Matthias BolzDepartment of Ophthalmology and Optometry, Kepler University Clinic, 4020 Linz, Austria.
Peter HinterdorferInstitute of Biophysics, Johannes Kepler University, 4020 Linz, Austria.ORCID 0000-0003-2583-1305
Yoo Jin OhInstitute of Biophysics, Johannes Kepler University, 4020 Linz, Austria.ORCID 0000-0002-9636-3329
Isaak FischingerDepartment of Ophthalmology and Optometry, Kepler University Clinic, 4020 Linz, Austria.

Funding

FWF Austrian Science Fund P30314
6 · The paper itself

Abstract

Uniaxial tensile testing and atomic force microscopy (AFM) nanoindentation experiments are two valuable methods used to quantify changes in stiffness after corneal crosslinking (CXL). Here, we apply these methods by characterizing corneal stiffness ex vivo before and after CXL. Sixty-two fresh porcine corneas were divided into three groups: an untreated control group, a CXL3 group treated with the Dresden protocol, and a CXL9 group treated with the accelerated protocol. Biomechanical testing was then performed using either uniaxial tensile testing or AFM nanoindentation. Uniaxial tensile testing revealed a significant increase in corneal stiffness for the CXL3 group compared to the control group (

Indexed as

atomic force microscopycorneal biomechanicscorneal crosslinkinguniaxial tensile test

Identifiers

PMID41463605
PMCPMC12729501

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.