Evidence map›Paper›PMID 41463485›Full record

ArticleBiology2025

The Interaction Between PGD2 and G6PD6 Is Involved in Aromatic Amino Acid Synthesis.

Qian Tang, Zhuanglin Shen, Jiaqin Huang, Dingxuan Zhang, Qiao Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qian TangSchool of Applied Biology, Shenzhen City Polytechnic, Shenzhen 518116, China.ORCID 0000-0001-7822-9700
Zhuanglin ShenCAS Key Laboratory for Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Jiaqin HuangSchool of Applied Biology, Shenzhen City Polytechnic, Shenzhen 518116, China.
Dingxuan ZhangSchool of Applied Biology, Shenzhen City Polytechnic, Shenzhen 518116, China.
Qiao ZhaoShenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Funding

Guangdong University Engineering Technology Research Center 2024GCZX016Shenzhen City Polytechnic Scientific Research Project BS22024005
6 · The paper itself

Abstract

The biosynthesis of AAAs in plants primarily relies on the shikimate pathway, with metabolic flux sustained by NADPH and E4P generated via the OPP pathway. However, how OPP enzymes coordinate to support AAA production remains unclear. Here, we investigated the direct interaction between two consecutive NADPH-producing enzymes, G6PD6 and PGD2, and its role in metabolic coupling. Using BiFC, Co-IP, pull-down assays, and domain mapping, we showed that G6PD6 and PGD2 form a cytosolic protein complex via the C-terminal domain of PGD2. Structural modeling identified potential interaction residues: PHE

Indexed as

Arabidopsis thalianaaromatic amino acidsG6PD6oxidative pentose phosphate pathwayPGD2protein–protein interaction

Identifiers

PMID41463485
PMCPMC12730105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.