Evidence map›Paper›PMID 41463483›Full record

ArticleBiology2025

Light, Dyes, and Action: Photodynamic Inactivation of

Deyvison Rhuan Vasco-Dos-Santos, Natália Vacani-Martins, Fabrício Cordeiro Moreira da Silva, Luiz Anastácio Alves, Zênis Novais da Rocha, Andrea Henriques-Pons, Eduardo Caio Torres-Santos, Marcos André Vannier-Santos

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deyvison Rhuan Vasco-Dos-SantosLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-9201-7584
Natália Vacani-MartinsLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0009-0004-5682-1331
Fabrício Cordeiro Moreira da SilvaLaboratório de Comunicação Celular, Instituto Oswaldo Cruz (LCC-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0009-0008-1671-0628
Luiz Anastácio AlvesLaboratório de Comunicação Celular, Instituto Oswaldo Cruz (LCC-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-0785-7272
Zênis Novais da RochaInstituto de Química, Universidade Federal da Bahia (UFBA), Campus Universitário de Ondina, Salvador 40170-290, BA, Brazil.ORCID 0000-0002-9236-8632
Andrea Henriques-PonsLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-9136-240X
Eduardo Caio Torres-SantosLaboratório de Bioquímica de Tripanossomatídeos, Instituto Oswaldo Cruz (LBqT-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0003-2240-4519
Marcos André Vannier-SantosLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-9241-2261

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 142350/2020-6; 310887/2023-2; 313188/2021-1; 314717/2020-0Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) 260003/001221/2023Programa Cientista do Nosso Estado (CNE) of Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) E26/201.158/2022; E26/204.392/2024Programa Inova Fiocruz, and the Instituto Oswaldo Cruz (IOC/Fiocruz) IOC-008-FIO-22-2-51
6 · The paper itself

Abstract

Photodynamic therapy (PDT), which combines light and dyes, has emerged as a cost-effective, selective, and less toxic alternative to conventional chemotherapy for cutaneous leishmaniasis (CL), offering potential benefits for millions, especially those who are socioeconomically vulnerable. Therefore, this study investigated the in vitro effects of methylene blue (MB), a widely used photosensitizer with proven clinical efficacy, along with its derivatives-new methylene blue-NMB, NMB-B, and NMB-P-in PDT against

Indexed as

apoptosiscell deathcutaneous leishmaniasisneglected tropical diseasesphotodynamic therapy

Identifiers

PMID41463483
PMCPMC12730387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.