Evidence map›Paper›PMID 41463482›Full record

ArticleBiology2025

From Dyes to Drugs? Selective Leishmanicidal Efficacy of Repositioned Methylene Blue and Its Derivatives in In Vitro Evaluation.

Deyvison Rhuan Vasco-Dos-Santos, Juliana Almeida-Silva, Ludmila Ferreira de Almeida Fiuza, Natalia Vacani-Martins, Zênis Novais da Rocha, Maria de Nazaré Correia Soeiro, Andrea Henriques-Pons, Eduardo Caio Torres-Santos, Marcos André Vannier-Santos

Abstract read
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Deyvison Rhuan Vasco-Dos-SantosLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-9201-7584
Juliana Almeida-SilvaLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0002-3922-3514
Ludmila Ferreira de Almeida FiuzaLaboratório de Biologia Celular, Instituto Oswaldo Cruz (LBC-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-6707-8556
Natalia Vacani-MartinsLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0009-0004-5682-1331
Zênis Novais da RochaInstituto de Química, Universidade Federal da Bahia (UFBA), Campus Universitário de Ondina, Salvador 40170-290, BA, Brazil.
Maria de Nazaré Correia SoeiroLaboratório de Biologia Celular, Instituto Oswaldo Cruz (LBC-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.
Andrea Henriques-PonsLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-9136-240X
Eduardo Caio Torres-SantosLaboratório de Bioquímica de Tripanossomatídeos, Instituto Oswaldo Cruz (LBqT-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0003-2240-4519
Marcos André Vannier-SantosLaboratório de Inovação em Terapias, Ensino e Bioprodutos, Instituto Oswaldo Cruz (LITEB-IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro 21040-900, RJ, Brazil.ORCID 0000-0001-9241-2261

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 260003/001221/2023Instituto Oswaldo Cruz IOC-008-FIO-22-2-51
6 · The paper itself

Abstract

Chemotherapy for cutaneous leishmaniasis is hindered by high toxicity, adverse effects, and increasing drug resistance. Thus, safer and more selective therapies are urgently required. Here, we evaluated the antiparasitic efficacy of methylene blue (MB) and new MB, as well as novel ruthenium complex derivatives (NMB-B and NMB-P) against promastigote and amastigote forms of

Indexed as

cell deathchemotherapycutaneous leishmaniasisLeishmania amazonensismethylene blueruthenium complexesselectivity

Identifiers

PMID41463482
PMCPMC12730333

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.