ReviewBiology2025
Factors Affecting Macro-Structural Development in the Cerebral Cortex: The Potential Role of Tissue Removal Through Pruning and Apoptosis.
Review in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Reduced gray matter in the prefrontal cortex and hippocampus: a potential neuroanatomical feature of insomnia comorbid with anxiety.Frontiers in psychiatry · 2026Article
- The role of sensory experience in the maturation of prefrontal cortical circuits.Frontiers in neuroscience · 2026Review
- Voxel-based and surface-based morphometric analyses reveal cortical-subcortical structural abnormalities and cognitive correlates in drug-naïve SeLECTS.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Several theories have been developed to explain mechanisms of macro-structural development in the cerebral cortex, including external skull constraints, axonal tension, differential proliferation of neural progenitors, differential cortical expansion, and axonal pushing. These theories are not necessarily mutually exclusive, and some combination thereof may be required in order to fully explain and characterize complex folding, sulcal development and thinning in the cortex. This manuscript provides an overview of the leading theories of contributing factors to macro-structural cortical development, and presents additional potential contributing factors, including tissue removal through pruning and apoptosis. Although tissue removal has been proposed as a potentially major factor in microcephaly and megalencephaly-conditions with major deviations from healthy macro-structural cortical development-in this manuscript, it is proposed that tissue removal may be an important factor in healthy neurodevelopment, as well as in additional pathological conditions. This manuscript also presents the theory that tissue removal may be linked to learning. Potential consequences for a variety of pathological conditions, and potential relationships with previously established theories of macro-structural cortical development are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.