Evidence map›Paper›PMID 41463395›Full record

ArticleBiomolecules2025

Systems-Level Integration of Multi-Omics Identifies Genetic Modifiers of TANGO2 Deficiency Disorder.

Manuel Airoldi, Heather Bondi, Veronica Remori, Silvia Carestiato, Giovanni Battista Ferrero, Alfredo Brusco, Mauro Fasano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manuel AiroldiDepartment of Science and High Technology, University of Insubria, 22100 Como, Italy.ORCID 0009-0001-0094-4576
Heather BondiDepartment of Science and High Technology, University of Insubria, 22100 Como, Italy.ORCID 0000-0002-4845-0022
Veronica RemoriDepartment of Science and High Technology, University of Insubria, 22100 Como, Italy.ORCID 0009-0009-5091-0030
Silvia CarestiatoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10124 Turin, Italy.ORCID 0000-0001-9475-6586
Giovanni Battista FerreroMedical Genetics Unit and Thalassemia Center, San Luigi University Hospital, 10049 Orbassano, Italy.ORCID 0000-0002-3793-5788
Alfredo BruscoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10124 Turin, Italy.ORCID 0000-0002-8318-7231
Mauro FasanoDepartment of Science and High Technology, University of Insubria, 22100 Como, Italy.ORCID 0000-0003-0628-5871

Funding

Ministero dell'università e della ricerca 20203P8C3X
6 · The paper itself

Abstract

TANGO2 deficiency disorder is a rare autosomal recessive disease (~100 cases reported worldwide). Despite being caused by loss-of-function variants in the

Indexed as

Mitochondrial ProteinsVesicular Transport ProteinsFemaleHumansLipid MetabolismMaleMultiomicsPedigreePhenotypeProtein Interaction MapsSystems BiologyMitochondrial ProteinsTANGO2 protein, humanVesicular Transport Proteinsgenetic modifiersmulti-omicsnetwork medicineTANGO2 deficiency disorder

Identifiers

PMID41463395
PMCPMC12730736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.