Evidence map›Paper›PMID 41463373›Full record

ArticleBiomolecules2025

Tuning Scaffold Properties of New 1,4-Substituted Pyrrolo[3,2-c]quinoline Derivatives Endowed with Anticancer Potential, New Biological and In Silico Insights.

Francesco Mingoia, Caterina Di Sano, Claudia D'Anna, Marco Fazzari, Alessia Bono, Gabriele La Monica, Annamaria Martorana, Antonino Lauria

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco MingoiaIstituto per lo Studio dei Materiali Nanostrutturati (ISMN), Consiglio Nazionale delle Ricerche (CNR), Via U. La Malfa 153, 90146 Palermo, Italy.ORCID 0000-0002-9106-4602
Caterina Di SanoIstituto di Farmacologia Traslazionale (IFT), Consiglio Nazionale delle Ricerche (CNR), Via U. La Malfa 153, 90146 Palermo, Italy.ORCID 0000-0003-3904-3465
Claudia D'AnnaIstituto di Farmacologia Traslazionale (IFT), Consiglio Nazionale delle Ricerche (CNR), Via U. La Malfa 153, 90146 Palermo, Italy.
Marco FazzariDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0002-4051-4431
Alessia BonoDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0002-9283-4920
Gabriele La MonicaDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0001-6510-1943
Annamaria MartoranaDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0002-9560-1882
Antonino LauriaDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze, Ed. 17, 90128 Palermo, Italy.ORCID 0000-0002-5116-6815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of angular tricyclic pyrrolo[3,2-c]quinoline derivatives (PQs) was designed and synthesized to further explore the previously promising antiproliferative activity exhibited by the 4-benzodioxole-substituted hit

Indexed as

Antineoplastic AgentsPyrrolesQuinolinesApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHeLa CellsHumansMCF-7 CellsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsPyrrolesQuinolinesanticancerbenzo[1,3]dioxole-5-ylclonogenic testHeLaMCF-7NCIpyrrolo[3,2-c]quinolinescratch test

Identifiers

PMID41463373
PMCPMC12730935

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.