Evidence map›Paper›PMID 41463364›Full record

ArticleBiomolecules2025

Vitamin B12-Loaded Chitosan Nanoparticles Promote Skeletal Muscle Injury Repair in Aged Rats via Amelioration of Aging-Suppressed Efferocytosis.

Walaa Bayoumie El Gazzar, Amina A Farag, Heba Bayoumi, Shaimaa E Radwaan, Lina Abdelhady Mohammed, Hend Elsayed Nasr, Nashwa E Ahmed, Reham M Ibrahim, Mahmoud Mostafa, Shimaa K Mohamed and 4 more

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Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Walaa Bayoumie El GazzarDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha 13518, Egypt.ORCID 0000-0001-5172-1105
Amina A FaragDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Benha University, Benha 13518, Egypt.ORCID 0000-0003-3014-9909
Heba BayoumiDepartment of Histology and Cell Biology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Shaimaa E RadwaanDepartment of Zoology, Faculty of Science, Benha University, Benha 13518, Egypt.ORCID 0000-0002-5632-3306
Lina Abdelhady MohammedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Hend Elsayed NasrDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Nashwa E AhmedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Reham M IbrahimDepartment of Physiology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Mahmoud MostafaDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0001-6425-9247
Shimaa K MohamedDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Helwan University, Cairo 11795, Egypt.
Dania AbdelhadyDepartment of Physiology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Eman E ElwakeelDepartment of Anatomy and Embryology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
Amira M BadrDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.ORCID 0000-0003-3983-868X
Sahar SolimanDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, USA.ORCID 0000-0002-0648-0979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle gradually loses its regenerative capacity with aging. Recent evidence highlights age-related immune dysregulation as a key driver of satellite cell dysfunction and reduced muscle regeneration. Timely elimination of apoptotic cells by phagocytes through efferocytosis is essential for tissue repair. Therefore, exploring age-related alterations in the molecular machinery of efferocytosis and their impact on muscle regeneration is of great relevance. This study examined the efferocytic machinery in the gastrocnemius muscle tissue of young and aged rats after doxorubicin-induced acute myotoxicity and assessed the potential of Vitamin B12-loaded chitosan nanoparticles (B12 CS NPS) to enhance efferocytosis and promote skeletal muscle injury repair in aged rats. Aged rats exhibited impaired efferocytosis with a significant reduction in

Indexed as

AgingChitosanMuscle, SkeletalNanoparticlesPhagocytosisVitamin B 12AnimalsEfferocytosisMalePPAR gammaRatsRats, Sprague-DawleyRegenerationChitosanPPAR gammaVitamin B 12agingdoxorubicinefferocytosismuscle regenerationskeletal musclevitamin B12

Identifiers

PMID41463364
PMCPMC12730411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.