ArticleBiomolecules2025
Mitochondrial DNA Damage and Histological Features in Liver Tissue of Azoxymethane-Treated
Carmen M Pérez-Pérez, Adlin Rodríguez-Muñoz, Gerardo G Mackenzie, Karen E Matsukuma, María R Castro-Achi, Sylvette Ayala-Peña, Carlos A Torres-Ramos
Abstract read
In one paragraphArticle in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Carmen M Pérez-PérezDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Adlin Rodríguez-MuñozDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Karen E MatsukumaDepartment of Pathology and Laboratory Medicine, University of California Davis, Davis, CA 95616, USA.
María R Castro-AchiDepartment of Pharmacology and Toxicology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Sylvette Ayala-PeñaDepartment of Pharmacology and Toxicology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.
Carlos A Torres-RamosDepartment of Physiology, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.ORCID 0000-0002-4792-1451 Funding
Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Abiel Roche-Lima · 2017 to 2026
$35.8MG-RISE at the University of Puerto Rico Medical Sciences CampusT32GM148406 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI BARRETO ESTRADA, JENNIFER LUZ, CADILLA, CARMEN LYDIA · 2023 to 2024
$2.8MAPE1 and Somatic Expansion in Huntington's DiseaseSC1NS127764 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI AYALA-PENA, SYLVETTE · 2022 to 2025
$1.4MNIGMS NIH HHS T32 GM148406NIH HHS 1SC1NS127764-22NIH HHS 1T32GM148406-15NIH HHS 1U54CA096297-15NIH HHS 1U54MD007600-15NIMHD NIH HHS U54 MD007600NINDS NIH HHS SC1 NS127764
6 · The paper itselfAbstract
Mitochondrial dysfunction and loss of mitochondrial DNA (mtDNA) integrity are increasingly recognized as key contributors to liver diseases such as cirrhosis and hepatocellular carcinoma. However, the role of mtDNA repair in maintaining mitochondrial homeostasis during liver injury remains poorly understood. Apurinic/apyrimidinic endonuclease 1 (APE1), encoded by the
Indexed as
AzoxymethaneDNA-(Apurinic or Apyrimidinic Site) LyaseDNA DamageDNA, MitochondrialHaploinsufficiencyLiverAnimalsDNA RepairMaleMiceMice, Inbred C57BLApex1 protein, mouseAzoxymethaneDNA-(Apurinic or Apyrimidinic Site) LyaseDNA, Mitochondrialbase excision repairlivermitochondria
Identifiers
PMID41463362
PMCPMC12731096
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