Long-Term Alterations of Glucocorticoid Receptor Expression and CD4
Mar M Sanchez, Leonidas Panagiotakopoulos, Timothy Hayes, Brittany R Howell, Kelly Ethun, Kirk A Easley, Guido Silvestri, Diane G Carnathan, Jackson McCandless, Jerrold Meyer and 1 more
Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Mar M SanchezDepartment of Psychiatry & Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30345, USA.ORCID 0000-0001-7701-2892
Leonidas PanagiotakopoulosDepartment of Pediatrics, Division of Pediatric Endocrinology, School of Medicine, Emory University, Atlanta, GA 30345, USA.
Timothy HayesDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30345, USA.
Brittany R HowellDepartment of Developmental and Cognitive Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, GA 30345, USA.ORCID 0000-0002-5643-2326
Kelly EthunDepartment of Developmental and Cognitive Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, GA 30345, USA.
Kirk A EasleyDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0003-4419-2617
Guido SilvestriDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30345, USA.
Diane G CarnathanDivision of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA 30345, USA.
Jackson McCandlessDepartment of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Jerrold MeyerDepartment of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Gretchen N NeighDepartment of Psychiatry & Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA 30345, USA.ORCID 0000-0003-0955-9161
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
National Institutes of Allergies and Infectious Diseases P30 AI027767-24National Institutes of Mental Health MH078105NIH HHS P51 OD011132Office of Research Infrastructure Programs/OD grant OD11132
6 · The paper itself
Abstract
Child maltreatment (MALT) is a devastating form of early-life adversity (ELA) and a primary risk for mental and physical illness. It is difficult to disentangle postnatal caregiving effects from heritable factors. Here we investigated the long-term effects of maternal care using a cross-fostering design to control for biological/heritable factors on immune function and inflammation during adolescence in a translational and naturalistic macaque model of MALT. We studied the impact of MALT on the immunophenotype of peripheral blood mononuclear cells (PBMCs) and assessed glucocorticoid receptor expression and function during adolescence. MALT was associated with elevated expression of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Long-Term Alterations of Glucocorticoid Receptor Expression and CD4 · full record | OpenQuestion