ArticleBiomolecules2025
Vitamin B12 Protects Against Early Diabetic Kidney Injury and Alters Clock Gene Expression in Mice.
Niroshani M W Wariyapperuma Appuhamillage, Anshulika A Deshmukh, Rachel L Moser, Qing Ma, Jiayi Zhou, Feng Li, Yukako Kayashima, Nobuyo Maeda
Abstract read
In one paragraphArticle in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Niroshani M W Wariyapperuma AppuhamillageDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anshulika A DeshmukhDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Rachel L MoserDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0009-6001-5582 Qing MaDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jiayi ZhouDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0009-7301-2698 Feng LiDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-6779-5077 Yukako KayashimaDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nobuyo MaedaDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2248-3299 Funding
MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5MBenefits of nicotinamide in placental development and in preeclamsiaR01HD101485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, FENG · 2021 to 2025
$2.1MNHLBI NIH HHS R01 HL049277NICHD NIH HHS R01 HD101485NIH HHS 5R01HL049277-33
6 · The paper itselfAbstract
Vitamin B12 (B12) is a strong antioxidant and a cofactor for methionine synthase supporting DNA/RNA/protein methylation. We previously demonstrated that oral high-dose B12 supplement mitigates diabetic cardiomyopathy in Akita diabetic mice expressing twice the normal levels of Elmo1 (Engulfment and cell motility 1). To assess how B12 prevents early kidney damage, we treated
Indexed as
CLOCK ProteinsDiabetes Mellitus, ExperimentalDiabetic NephropathiesVitamin B 12AnimalsCircadian RhythmGene Expression RegulationMaleMiceClock protein, mouseCLOCK ProteinsVitamin B 12circadian rhythmdiabetic nephropathyVitamin B12
Identifiers
PMID41463345
PMCPMC12731228
What OpenQuestion holds
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LicenceCC BY
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