Evidence map›Paper›PMID 41463321›Full record

ArticleBiomolecules2025

Developmental Toxicity of Ibrutinib: Insights from Stem Cell Dynamics and Neural Regeneration in Planarians.

Weiyun Guo, Baijie Jin, Nannan Li, Dandan Sun, Dezeng Liu, Zimei Dong, Guangwen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in ecotoxicological research using planarians: a comprehensive review.Environmental science and pollution research international · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weiyun GuoCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Baijie JinCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Nannan LiCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Dandan SunCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Dezeng LiuCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Zimei DongCollege of Life Science, Henan Normal University, Xinxiang 453007, China.
Guangwen ChenCollege of Life Science, Henan Normal University, Xinxiang 453007, China.

Funding

National Natural Science Foundation of China 32070427National Natural Science Foundation of China 32470463the Major Public Welfare Project of Henan Province 201300311700the National Natural Science Foundation of China 32270501
6 · The paper itself

Abstract

Ibrutinib (IB), a Bruton's tyrosine kinase (BTK) inhibitor, is widely used against B-cell malignancies. However, its adverse effects on stem cell-dependent processes and tissue homeostasis remain incompletely understood. Freshwater planarians possess pluripotent stem cells (neoblasts), which enable remarkable regeneration of various tissues, including the central nervous system. This makes them ideal in vivo models for studying chemical toxicity within a whole-organism context. Here, we utilized planarian

Indexed as

AdenineNerve RegenerationPiperidinesStem CellsAgammaglobulinaemia Tyrosine KinaseAnimalsApoptosisCell DifferentiationCell ProliferationCentral Nervous SystemOxidative StressPlanariansProtein Kinase InhibitorsRNA InterferenceAdenineAgammaglobulinaemia Tyrosine KinaseibrutinibPiperidinesProtein Kinase InhibitorsBTKibrutinibplanarianstem cellstoxicity

Identifiers

PMID41463321
PMCPMC12731123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.