Lipopolysaccharide Potentiates Platelet Aggregation in Association with Apoptosis Through a Novel TLR4-Bax/Bcl-2-Mitochondrial Dysfunction Axis in Humans.

Chun-Chao Chen, Chih-Wei Hsia, Wei-Chieh Huang, Chao-Chien Chang, Arief Gunawan Darmanto, Joen-Rong Sheu

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chun-Chao ChenGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Chih-Wei HsiaDepartment of Medical Research, Taipei Medical University Hospital, Taipei 110, Taiwan.

Wei-Chieh HuangGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Chao-Chien ChangDepartment of Cardiovascular Center, Cathay General Hospital, Taipei 106, Taiwan.

Arief Gunawan DarmantoSchool of Medicine, Universitas Ciputra, Surabaya 60219, Indonesia.ORCID 0009-0002-3356-9335

Joen-Rong SheuGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0001-8265-3678

Funding

National Science and Technology Council, Taiwan NSTC 112-2320-B-038-037-MY3National Science and Technology Council, Taiwan NSTC 114-2320-B-038-011Taipei Medical University DP2-15TMU-112-N-11Taipei Medical University DP2-TMU-113-T-04Taipei Medical University TMU111-AE1-B08Taipei Medical University-Shuang Ho Hospital 111TMU-SHH-11

6 · The paper itself

Abstract

Platelets are anucleate cells whose dysregulation contributes to thrombocytopenia during sepsis. Thrombocytopenia is an early complication of Gram-negative infection, in which lipopolysaccharide (LPS) serves as a principal mediator; however, its precise contribution remains unclear. In this study, LPS, at concentration 10 µg/mL, did not induce human platelet aggregation but significantly potentiated low-dose collagen (0.5 μg/mL)-induced aggregation, ATP release, intracellular calcium levels ([Ca

Indexed as

Apoptosisbcl-2-Associated X ProteinLipopolysaccharidesMitochondriaPlatelet AggregationProto-Oncogene Proteins c-bcl-2Toll-Like Receptor 4Blood PlateletsCalciumHumansSignal TransductionBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCalciumLipopolysaccharidesProto-Oncogene Proteins c-bcl-2TLR4 protein, humanToll-Like Receptor 4Bax/Bcl-2caspase-8/3human plateletsLPSmitochondrial dysfunctionplatelet apoptosis

Identifiers

PMID41463294

DOI10.3390/biom15121638

PMCPMC12730485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.