ArticleCancers2025
Association of Breast Density with Breast Cancer Risk and Stage at Diagnosis: A Korean Nationwide Cohort Study.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Postpartum breast cancer as a distinct oncologic entity: linking physiological tissue remodelling to tumor biology and clinical translation.Breast cancer research : BCR · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
BACKGROUND/
objectivesBreast density, as defined by the Breast Imaging Reporting and Data System (BI-RADS), reduces mammographic sensitivity and is a risk factor for breast cancer. However, its association with cancer risk and stage at diagnosis remains debated, with limited large-scale evidence.
methodsWe conducted a nationwide retrospective cohort study of 952,755 Korean women who underwent screening mammography between 2013 and 2014, with breast cancer diagnoses identified over a 5-year follow-up period. Breast density was categorized by BI-RADS criteria (A-D). Breast cancer risk was evaluated using logistic regression, with odds ratios representing relative odds of developing breast cancer during the 5-year interval. Stage at diagnosis was classified as localized versus regional/distant disease according to national cancer registry records.
resultsDuring 5 years of follow-up, 11,286 women (1.2%) were diagnosed with breast cancer. Higher breast density was significantly associated with increased breast cancer risk: multivariable-adjusted odds ratios (ORs) were 1.174 (95% CI, 1.093-1.260), 1.268 (95% CI, 1.186-1.356), and 1.287 (95% CI, 1.196-1.385) for BI-RADS B-D, respectively, compared with BI-RADS A (all
conclusionsHigher breast density was independently associated with increased breast cancer risk but not with advanced-stage disease at diagnosis. These findings underscore the importance of individualized screening strategies for women with dense breasts.
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