Evidence map›Paper›PMID 41463076›Full record

ReviewBiomedicines2025

Adipose-Specific Cytokines as Modulators of Reproductive Activity.

Marcelo Martinez-Barbitta, Andrea Biagini, Egidia Costanzi, Margherita Maranesi, Juan García-Díez, Cristina Saraiva, Beniamino Cenci Goga, Massimo Zerani

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcelo Martinez-BarbittaSistema Reproductivo Veterinario Integral Uruguay, SRVI_UY, Nueva Helvecia 70300, Uruguay.ORCID 0000-0001-6524-8929
Andrea BiaginiDottorato di Ricerca in Patologie Infiammatorie ed Infettive, Strategie Terapeutiche e Biodiritto, Università di Perugia, 06121 Perugia, Italy.ORCID 0000-0002-7937-2784
Egidia CostanziDipartimento di Medicina Veterinaria, Università di Perugia, 06121 Perugia, Italy.
Margherita MaranesiDipartimento di Medicina Veterinaria, Università di Perugia, 06121 Perugia, Italy.ORCID 0000-0002-1727-4118
Juan García-DíezCentro de Ciência Animal e Veterinária, Universidade de Trás-os-Montes e Alto Douro, 5000-911 Vila Real, Portugal.ORCID 0000-0002-6930-0728
Cristina SaraivaCentro de Ciência Animal e Veterinária, Universidade de Trás-os-Montes e Alto Douro, 5000-911 Vila Real, Portugal.ORCID 0000-0003-1657-0684
Beniamino Cenci GogaDipartimento di Medicina Veterinaria, Università di Perugia, 06121 Perugia, Italy.ORCID 0000-0002-3993-6258
Massimo ZeraniDipartimento di Medicina Veterinaria, Università di Perugia, 06121 Perugia, Italy.ORCID 0000-0002-2476-5097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue is characterized by specialized lipid handling cells called adipocytes, which function as the primary energy reservoir. Like many other cell types, adipocytes have highly plastic properties, such as the conversion of white adipocytes into brown or beige adipocytes, which produce heat, and pink adipocytes into mammary cells synthesizing and secreting milk. Highly specialized adipose tissue depots are present in various species, such as male orangutans with prominent fat-filled facial flanges indicating hierarchical status, or cetaceans with the melon, a specialized adipose tissue for echolocation. Adipose tissue is now considered a true endocrine organ that regulates various physiological mechanisms through the hormonal secretion of adipokines, which modulate systemic metabolism and physiological processes. In particular, the role of adipokines in the control of the reproductive axis and their participation in the regulation of fertility have been widely reported. This review summarizes the current state of research on the effects of adipose-specific cytokines on the male and female reproductive systems.

Indexed as

adipokinesadiponectinleptinomentinreproductionresistinvisfatinwhite adipose tissue

Identifiers

PMID41463076
PMCPMC12730299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.