Evidence map›Paper›PMID 41463046›Full record

ArticleBiomedicines2025

Dual Modulation of Cardiac Ion Pumps: A Small-Molecule SERCA2a SUMOylation Enhancer Also Inhibits the Na

Carlos Cruz-Cortés, Jaroslava Šeflová, L Michel Espinoza-Fonseca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carlos Cruz-CortésDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Jaroslava ŠeflováDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL 60153, USA.ORCID 0000-0001-5486-0864
L Michel Espinoza-FonsecaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

Mechanisms and discovery of small-molecule effectors targeting cardiac ion pumpsR01HL176212 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lennane Michel Espinoza-Fonseca · 2024 to 2026
$1.7M
National Heart Lung and Blood Institute R01HL176212NHLBI NIH HHS R01 HL176212
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiac contractilitydual effectorsinhibitorinotropic modulationNa+/K+-ATPaseSERCA2a

Identifiers

PMID41463046
PMCPMC12731165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.