ArticleChildren (Basel, Switzerland)2025
Assessing Hepatic Steatosis Following Weight Loss in Adolescents with Severe Obesity: A Randomized Controlled Trial.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesTo assess whether laparoscopic adjustable gastric banding (LAGB) and combined lifestyle intervention (CLI) reduce hepatic steatosis more effectively than CLI alone in adolescents with severe obesity.
methodsAdolescents aged 14-16 with a BMI ≥ 40 kg/m
resultsOf 59 participants (mean age 15.7, 80% female, BMI 44.3 kg/m
conclusionsLAGB led to greater reductions in hepatic fat and size than lifestyle changes alone. Though steatosis resolution was not statistically significant, findings suggest bariatric surgery may be a promising strategy for mitigating early hepatic changes in severe adolescent obesity. WHAT IS ALREADY KNOWN: Severe obesity in adolescents is frequently accompanied by hepatic steatosis, which can progress to metabolic dysfunction-associated steatotic liver disease (MASLD). Bariatric procedures-such as laparoscopic adjustable gastric banding (LAGB)-are proven to induce substantial weight loss and improve obesity-related comorbidities in youth. WHAT THIS STUDY ADDS: This is the first randomized controlled trial to evaluate the effect of LAGB on hepatic steatosis specifically in adolescents. At one year, 21.4% of LAGB-treated patients no longer met the sensitive HRI cut-off for steatosis (<1.05) versus 4.4% of controls. Moderate weight loss after LAGB corresponded with significant improvements in the Hepatorenal Index and liver span, suggesting a reduction in hepatic fat content.
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