Evidence map›Paper›PMID 41462690›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Lifetime Deletion of Skeletal Muscle Keap1 Attenuates Aging-Induced Cardiac Dysfunction via an Nrf2-Antioxidant Mechanism.

Kanika Sharma, Sarah Pribil Pardun, Neha Dhyani, Irving H Zucker, Bipin G Nair, Sudarslal Sadasivan Nair, Vikas Kumar, Lie Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kanika SharmaAmrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Kollam 690525, Kerala, India.
Sarah Pribil PardunDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0009-0003-4528-4836
Neha DhyaniDepartment of Cellular & Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-0853-5758
Irving H ZuckerDepartment of Cellular & Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-3636-7720
Bipin G NairAmrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Kollam 690525, Kerala, India.
Sudarslal Sadasivan NairAmrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Kollam 690525, Kerala, India.
Vikas KumarDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Shrewsbury, MA 01545, USA.
Lie GaoDepartment of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0002-7880-7213

Funding

Skeletal Muscle Nrf2: Exercise-Induced Cardiovascular ProtectionR01HL160820 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GAO, LIE · 2022 to 2025
$2.1M
NIH HHS R01HL160820
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agingcardiac dysfunctioninterorgan antioxidant crosstalkKeap1 knockoutmyocardial proteomicsnuclear factor erythroid 2-related factor

Identifiers

PMID41462690
PMCPMC12729826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.