Molecular Insights into the Genesis of Heat Hardening in Marine Bivalves.

Ioannis Georgoulis, Ioannis A Giantsis, Basile Michaelidis, Athanasios Kouniakis, Konstantinos Feidantsis

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Tissue-Specific Trade-Offs Between Biomineralisation and Antioxidant Responses inAntioxidants (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ioannis GeorgoulisLaboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-9012-8061

Ioannis A GiantsisLaboratory of Ichthyology & Fisheries, Faculty of Agriculture, Forestry and Natural Environment, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-6323-2955

Basile MichaelidisLaboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.ORCID 0000-0002-2312-6883

Athanasios KouniakisDepartment of Fisheries & Aquaculture, School of Agricultural Sciences, University of Patras, GR-26504 Mesolonghi, Greece.

Konstantinos FeidantsisDepartment of Fisheries & Aquaculture, School of Agricultural Sciences, University of Patras, GR-26504 Mesolonghi, Greece.ORCID 0000-0001-7606-0024

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat hardening induces complex biochemical reprogramming that enhances thermal resilience in marine bivalves. Despite this technique's promising results in marine animals, the molecular basis of heat hardening is far from understood. This study elucidates the molecular mechanisms underlying the hardening process in

Indexed as

antioxidant defenseautophagycell death responsesgene expressionhardening genesheat shock responseMediterranean musselmitochondrial metabolismmRNA levelsoxidative stress

Identifiers

PMID41462667

DOI10.3390/antiox14121468

PMCPMC12730068

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.