Evidence map›Paper›PMID 41462654›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Selective Head Cooling and NOX Inhibition Protect the Blood-Brain Barrier in Neonatal Epilepsy.

Helena Parfenova, Jianxiong Liu, Shyamali Basuroy, Rong Zhang, Mimily Harsono, Massroor Pourcyrous

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Helena ParfenovaDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0000-0002-8623-8305
Jianxiong LiuDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0007-0050-5833
Shyamali BasuroyDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Rong ZhangDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Mimily HarsonoDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Massroor PourcyrousDepartments of Physiology and Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.ORCID 0009-0005-8806-9890

Funding

Endothelial Vasoprotection by HypothermiaR01NS105655 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI PARFENOVA, HELENA · 2018 to 2022
$2.1M
Neonatal cerebral vascular injury by prolonged asphyxiaR01NS134659 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Helena Parfenova · 2024 to 2026
$1.5M
NIH/NINDS R01NS105655, R01NS134659NINDS NIH HHS R01 NS105655NINDS NIH HHS R01 NS134659
6 · The paper itself

Abstract

Epileptic seizures in the neonatal brain induce oxidative stress and disrupt the blood-brain barrier (BBB), leading to long-term cerebrovascular and neurodevelopmental deficits. This study examined the protective effects of selective head cooling and NADPH oxidase (NOX) inhibition on BBB integrity following seizures. Neonatal seizures were induced in newborn pigs with bicuculline under normothermic or selective head cooling conditions. BBB disruption was assessed by Evans Blue extravasation and quantification of circulating brain-derived endothelial cells (CD45

Indexed as

antioxidantsendothelial dysfunctionepilepsyhypothermiaoxidative stresssetanaxibsulforaphane

Identifiers

PMID41462654
PMCPMC12729707

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.