Evidence map›Paper›PMID 41462606›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Synthetic Oleanane Triterpenoids Reduce Tumor Growth and Promote an Anti-Tumor Immune Response Independent of Cancer

Christopher J Occhiuto, Jessica A Moerland, Karen T Liby, Ana S Leal

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher J OcchiutoDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-2218-4504
Jessica A MoerlandDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8085-3470
Karen T LibyDivision of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3317-3437
Ana S LealDivision of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-6472-2879

Funding

NIH HHS 1F31CA275239-22NIH HHS 1R01CA226690-19United States Department of Defense HT9425-23-1-0273United States Department of Defense W81XWH-22-1-0027
6 · The paper itself

Abstract

KEAP1 negatively regulates the cytoprotective factor NRF2 and is commonly inactivated in lung cancer cells. Loss-of-function

Indexed as

CDDO-Meimmune systemKEAP1lung cancermacrophagesNRF2triterpenoids

Identifiers

PMID41462606
PMCPMC12729418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.