Evidence map›Paper›PMID 41462596›Full record

ArticleAntioxidants (Basel, Switzerland)2025

NADK Governs Ferroptosis Susceptibility by Orchestrating NADPH Homeostasis.

Xinyi Chen, Yingying Zhang, Dandan Song, Fei Gui, Yuejia Cao, Yu Hong, Rong Chen, Yang Song, Chunhong Di, Jun Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinyi ChenSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Yingying ZhangSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Dandan SongSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Fei GuiLaboratory Animal Center, Hangzhou Normal University, Hangzhou 311121, China.
Yuejia CaoSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Yu HongSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Rong ChenSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Yang SongSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.
Chunhong DiThe Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China.ORCID 0000-0002-6837-3730
Jun YangSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-9401-3528
Xiaohua TanSchool of Public Health and Nursing, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-3864-5301

Funding

Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation LHDMZ24H040001National Natural Science Foundation of China 32270186National Natural Science Foundation of China 81772168Zhejiang Provincial Natural Science Foundation LQ18H190003Zhejiang Provincial Natural Science Foundation LY23H190001
6 · The paper itself

Abstract

Ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, is modulated by cellular antioxidant systems, particularly the glutathione (GSH)-glutathione peroxidase 4 (GPX4) axis. NAD kinase (NADK), the only enzyme converting NAD

Indexed as

ferroptosislipid peroxidationNAD kinase 1NADPHredox homeostasis

Identifiers

PMID41462596
PMCPMC12730079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.