ReviewAntioxidants (Basel, Switzerland)2025
SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk.
Abstract readReview
In one paragraph
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- SHP-2 Expression Is a Positive Prognostic Biomarker in Non-Small-Cell Lung Carcinoma: Association with KRAS Mutation and Prolonged Survival.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Silvia Fernanda López MorenoDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0009-0005-9258-3016
Stefania Assunto LenzDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Bernardo Casso-ChapaDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0009-0005-3375-3724
Angelica Paniagua-BojorgesDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0009-0008-7539-8646
Jung Hyun KimDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0009-0006-8526-1315
Nicolas L PalaskasDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0000-0001-7565-1797
Kevin T NeadDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0001-9680-8298
Venkata S K SamanthapudiDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Gilbert MejiaDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Oanh HoangDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0000-0001-5304-585X
Jonghae LeeDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0000-0002-1182-9653
Steven H LinDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0003-4411-0634
Joerg HerrmannCardio Oncology Clinic, Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Guangyu WangDepartment of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.
Syed Wamique YusufDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Cezar A IliescuDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0000-0002-8817-4579
Noah I BeinartDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Charlotte ManistyInstitute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Masuko Ushio-FukaiDepartment of Medicine, Cardiology, Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Tohru FukaiDepartment of Medicine, Cardiology, Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9864-571X
Pietro AmeriCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0001-7167-7287
Roza I NurievaDepartment of Immunology, Division of Discovery Science, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Michelle A T HildebrandtDepartment of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Keri SchadlerDepartment of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-1675-0514
Efstratios KoutroumpakisDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Sivareddy KotlaDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.
Nhat-Tu LeDepartment of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX 77030, USA.ORCID 0000-0001-7746-7328
Jun-Ichi AbeDepartment of Cardiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1057, Houston, TX 77030, USA.ORCID 0000-0001-7439-7774
Funding
Sex and Leptin control of endothelial cell glycolysis and redox balance in Type 1 DiabetesP01HL160557 · NHLBI · AUGUSTA UNIVERSITY · PI TOHRU FUKAI, Masuko Ushio-Fukai · 2024 to 2026
$9.0MPremature aging disorders, metabolites, and atherosclerosisR01HL163857 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Jun-Ichi Abe, JOHN P COOKE · 2023 to 2026
$2.9MMitigating radiation-induced cardiovascular disease by inhibiting premature agingU01AI156921 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ABE, JUN-ICHI · 2020 to 2024
$2.5MCu uptake transporter as a disturbed flow sensor in vascular inflammatory diseaseR01HL174014 · NHLBI · AUGUSTA UNIVERSITY · PI TOHRU FUKAI, Masuko Ushio-Fukai · 2024 to 2026
$2.3MMitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and AngiogenesisR01HL160014 · NHLBI · AUGUSTA UNIVERSITY · PI USHIO-FUKAI, MASUKO · 2021 to 2024
$2.0MAmerican Heart Association-American Stroke Association 971863BLRD VA I01 BX001232Italian Ministry of Health NAMiami Heart Research Foundation NANational Institutes of Health Research BioMedical Research Centre at University College Hospitals London NANHLBI NIH HHS P01 HL160557NHLBI NIH HHS R01 HL160014NHLBI NIH HHS R01 HL163857NHLBI NIH HHS R01 HL174014NIAID NIH HHS U01 AI156921NIH HHS 1P01HL160557-01NIH HHS 1R01CA233610-01NIH HHS 1R01CA240941-01NIH HHS 1R01HL134740-04NIH HHS 1R01HL147550-02NIH HHS 1R01HL149303-04NIH HHS 1R01HL160014-01NIH HHS 1R01HL174014-02NIH HHS 1U01AI156921-05the University of Texas MD Anderson Cancer Center Institutional Research Grant (IRG) ProgramUnited States Department of Defense HT9425-25-1-0309Veterans for America I01BX001232
Abstract
Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the
Indexed as
and cardiovascular diseasecancerICIoxidative stressPD-1PD-L1scaffold proteinSHP2 tyrosine phosphatase
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.