ArticleInternational journal of retina and vitreous2025
Concentric macular rings and OCT corrugations in foveal hypoplasia: proof of concept for an optical interference mechanism.
Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Haidinger's brushes in albinism: altered perception patterns in single cases.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
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6 authors.
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Abstract
backgroundConcentric macular rings (CMR) and Henle fiber layer (HFL) corrugations, potential clinical biomarkers of foveal hypoplasia, have been observed in laser fundus photographs and optical coherence tomography (OCT) images, respectively. Some believe these findings represent true anatomical structural changes while others hypothesize that they are artifacts of interference; however, to our knowledge, no previous study has provided evidence to support either theory.
methodsThis retrospective case series analyzed CMR and OCT corrugations in 3 patients (6 eyes) with foveal hypoplasia. Dark fringe diameters of CMR at different wavelengths (λ: red = 635, green = 532, blue = 488 nm) and OCT corrugations of the first five dark fringes were measured. Dark fringe diameter was compared to fringe order (n) and λ using linear regression and t-tests.
resultsCMR fringe measurements demonstrated linear relationships between radius2 (r2) and fringe order at all wavelengths (mean R2: 0.949, SD: 0.022, range: 0.911–0.985). OCT corrugation measurements also exhibited strong linearity with fringe order (R2 = 0.998, 0.946). Fringe r2 increased with wavelength but exceeded theoretical predictions (p < 0.05), especially among ratios including shorter λ (mean difference r2 red:green = 0.104, green:blue = 0.292, red:blue = 0.468).
conclusionsThis study is the first to provide evidence supporting an etiologic mechanism of CMR and HFL corrugations, showing correlation with physical phenomena of interference. CMR and HFL corrugations correlate with fringe order (n) and λ in a manner consistent with Newton’s rings (r2 = nR’λ, r = radius, R’ = radius of curvature), suggesting these phenomena are imaging artifacts. Further research validating these results will be important.
trial registrationThis study does not report the results of a health care intervention on human participants. CLINICAL TRIAL DISCLOSURE: This study does not report results of a clinical trial.
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